Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | RHOXF1 | Rhox homeobox family, member 1; May be a transcription factor involved in reproductive processes (184 aa) | ||||||||||||
Predicted Functional Partners:
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 | SRF | serum response factor (c-fos serum response element-binding transcription factor); SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5’ of the site of transcription initiation of some genes (such as FOS). Required for cardiac differentiation and maturation (508 aa) |
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0.696 | |||||||||
 | UNC5C | unc-5 homolog C (C. elegans); Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity) (931 aa) |
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0.562 | ||||||||||
 | SPATA19 | spermatogenesis associated 19; May have a role in spermiogenesis (167 aa) |
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0.509 | ||||||||||
 | FBXO39 | F-box protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) (442 aa) |
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0.457 | ||||||||||
 | LEMD1 | LEM domain containing 1 (181 aa) |
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0.414 | ||||||||||
 | MAGEA9 | melanoma antigen family A, 9; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression (315 aa) |
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0.405 | ||||||||||
 | FOXD1 | forkhead box D1; Transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney. Can neuralize ectodermal cells directly (By similarity) (459 aa) |
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0.402 | |||||||||
 | FOXR2 | forkhead box R2 (311 aa) |
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0.402 | |||||||||
 | FOXI2 | forkhead box I2; Possible transcriptional activator (By similarity) (318 aa) |
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0.402 | |||||||||
 | FOXD4 | forkhead box D4 (439 aa) |
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0.402 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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