node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCD1 | ABCD2 | ENSP00000218104 | ENSP00000310688 | ATP-binding cassette, sub-family D (ALD), member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | 0.578 |
ABCD1 | ABCD3 | ENSP00000218104 | ENSP00000359233 | ATP-binding cassette, sub-family D (ALD), member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | 0.602 |
ABCD1 | ACSBG1 | ENSP00000218104 | ENSP00000258873 | ATP-binding cassette, sub-family D (ALD), member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids | 0.543 |
ABCD1 | ACSL1 | ENSP00000218104 | ENSP00000281455 | ATP-binding cassette, sub-family D (ALD), member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | acyl-CoA synthetase long-chain family member 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate | 0.557 |
ABCD1 | ACSL3 | ENSP00000218104 | ENSP00000350012 | ATP-binding cassette, sub-family D (ALD), member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | acyl-CoA synthetase long-chain family member 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) | 0.557 |
ABCD1 | ACSL4 | ENSP00000218104 | ENSP00000339787 | ATP-binding cassette, sub-family D (ALD), member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates | 0.557 |
ABCD1 | ACSL5 | ENSP00000218104 | ENSP00000348429 | ATP-binding cassette, sub-family D (ALD), member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | acyl-CoA synthetase long-chain family member 5; Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine [...] | 0.557 |
ABCD1 | ACSL6 | ENSP00000218104 | ENSP00000296869 | ATP-binding cassette, sub-family D (ALD), member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | acyl-CoA synthetase long-chain family member 6; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid | 0.557 |
ABCD1 | PEX14 | ENSP00000218104 | ENSP00000349016 | ATP-binding cassette, sub-family D (ALD), member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 | 0.572 |
ABCD1 | PEX19 | ENSP00000218104 | ENSP00000357051 | ATP-binding cassette, sub-family D (ALD), member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | 0.762 |
ABCD2 | ABCD1 | ENSP00000310688 | ENSP00000218104 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | ATP-binding cassette, sub-family D (ALD), member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | 0.578 |
ABCD2 | ABCD3 | ENSP00000310688 | ENSP00000359233 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity | 0.622 |
ABCD2 | ACSBG1 | ENSP00000310688 | ENSP00000258873 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids | 0.906 |
ABCD2 | ACSL1 | ENSP00000310688 | ENSP00000281455 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | acyl-CoA synthetase long-chain family member 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate | 0.589 |
ABCD2 | ACSL3 | ENSP00000310688 | ENSP00000350012 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | acyl-CoA synthetase long-chain family member 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis (By similarity). Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates (By similarity). Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) | 0.557 |
ABCD2 | ACSL4 | ENSP00000310688 | ENSP00000339787 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates | 0.557 |
ABCD2 | ACSL5 | ENSP00000310688 | ENSP00000348429 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | acyl-CoA synthetase long-chain family member 5; Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine [...] | 0.557 |
ABCD2 | ACSL6 | ENSP00000310688 | ENSP00000296869 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | acyl-CoA synthetase long-chain family member 6; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid | 0.557 |
ABCD2 | PEX14 | ENSP00000310688 | ENSP00000349016 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17 | 0.688 |
ABCD2 | PEX19 | ENSP00000310688 | ENSP00000357051 | ATP-binding cassette, sub-family D (ALD), member 2; Probable transporter | peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53 | 0.966 |