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KCNIP4 KCNIP4 KCNIP2 KCNIP2 KCNIP1 KCNIP1 PTX3 PTX3 AGT AGT KCND1 KCND1 NCS1 NCS1 KCNH1 KCNH1 IL16 IL16 IRX2 IRX2 AKAP5 AKAP5
"KCND1" - potassium voltage-gated channel, Shal-related subfamily, member 1 in Homo sapiens
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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KCND1potassium voltage-gated channel, Shal-related subfamily, member 1; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits (647 aa)    
Predicted Functional Partners:
KCNIP1
Kv channel interacting protein 1; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface (227 aa)
         score_image   score_image   0.865
PTX3
pentraxin 3, long; Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility (By similarity) (381 aa)
         score_image   score_image   0.837
KCNIP4
Kv channel interacting protein 4 (250 aa)
         score_image   score_image   0.791
AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis (485 aa)
             score_image   0.680
IRX2
iroquois homeobox 2 (471 aa)
             score_image   0.638
AKAP5
A kinase (PRKA) anchor protein 5; May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade (427 aa)
             score_image   0.616
NCS1
neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel (By similarity) (190 aa)
         score_image   score_image   0.598
IL16
interleukin 16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 (1332 aa)
         score_image       0.573
KCNIP2
Kv channel interacting protein 2 (285 aa)
         score_image   score_image   0.554
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts (989 aa)
         score_image   score_image   0.538
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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