PQBP1 protein (Homo sapiens) - STRING network view

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Score

PQBP1

polyglutamine binding protein 1 (265 aa)

Predicted Functional Partners:

TXNL4A

0.969

CD2BP2

0.912

SF3A2

0.897

AQR

0.759

WDR77

0.725

FTSJ1

0.652

PPIL4

0.590

ZNF41

0.586

WBP11

0.572

ATXN1

0.556

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AQR	PQBP1	ENSP00000156471	ENSP00000218224	aquarius homolog (mouse); Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing	polyglutamine binding protein 1	0.759
AQR	WDR77	ENSP00000156471	ENSP00000235090	aquarius homolog (mouse); Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing	WD repeat domain 77; Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor [...]	0.702
ATXN1	PQBP1	ENSP00000244769	ENSP00000218224	ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function	polyglutamine binding protein 1	0.556
CD2BP2	PQBP1	ENSP00000304903	ENSP00000218224	CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly	polyglutamine binding protein 1	0.912
CD2BP2	SF3A2	ENSP00000304903	ENSP00000221494	CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly	splicing factor 3a, subunit 2, 66kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex	0.989
CD2BP2	TXNL4A	ENSP00000304903	ENSP00000269601	CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly	thioredoxin-like 4A; Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly	0.997
CD2BP2	WBP11	ENSP00000304903	ENSP00000261167	CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly	WW domain binding protein 11; Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity	0.623
FTSJ1	PQBP1	ENSP00000326948	ENSP00000218224	FtsJ RNA methyltransferase homolog 1 (E. coli)	polyglutamine binding protein 1	0.652
FTSJ1	ZNF41	ENSP00000326948	ENSP00000315173	FtsJ RNA methyltransferase homolog 1 (E. coli)	zinc finger protein 41	0.562
PPIL4	PQBP1	ENSP00000253329	ENSP00000218224	peptidylprolyl isomerase (cyclophilin)-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)	polyglutamine binding protein 1	0.590
PQBP1	AQR	ENSP00000218224	ENSP00000156471	polyglutamine binding protein 1	aquarius homolog (mouse); Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing	0.759
PQBP1	ATXN1	ENSP00000218224	ENSP00000244769	polyglutamine binding protein 1	ataxin 1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function	0.556
PQBP1	CD2BP2	ENSP00000218224	ENSP00000304903	polyglutamine binding protein 1	CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly	0.912
PQBP1	FTSJ1	ENSP00000218224	ENSP00000326948	polyglutamine binding protein 1	FtsJ RNA methyltransferase homolog 1 (E. coli)	0.652
PQBP1	PPIL4	ENSP00000218224	ENSP00000253329	polyglutamine binding protein 1	peptidylprolyl isomerase (cyclophilin)-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)	0.590
PQBP1	SF3A2	ENSP00000218224	ENSP00000221494	polyglutamine binding protein 1	splicing factor 3a, subunit 2, 66kDa; Subunit of the splicing factor SF3A required for ’A’ complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the ’E’ complex	0.897
PQBP1	TXNL4A	ENSP00000218224	ENSP00000269601	polyglutamine binding protein 1	thioredoxin-like 4A; Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly	0.969
PQBP1	WBP11	ENSP00000218224	ENSP00000261167	polyglutamine binding protein 1	WW domain binding protein 11; Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity	0.572
PQBP1	WDR77	ENSP00000218224	ENSP00000235090	polyglutamine binding protein 1	WD repeat domain 77; Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor [...]	0.725
PQBP1	ZNF41	ENSP00000218224	ENSP00000315173	polyglutamine binding protein 1	zinc finger protein 41	0.586

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