Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
|||||
 | RAB40AL | RAB40A, member RAS oncogene family-like; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity) (278 aa) | ||||||||||||
Predicted Functional Partners:
| ||||||||||||||
 | RAB3IP | RAB3A interacting protein (rabin3) (476 aa) |
 |
|
0.958 | |||||||||
 | FYCO1 | FYVE and coiled-coil domain containing 1; May mediate microtubule plus end-directed vesicle transport (1478 aa) |
|
0.860 | ||||||||||
 | EXOC7 | exocyst complex component 7 (735 aa) |
|
|
0.819 | |||||||||
 | EXOC2 | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (924 aa) |
|
|
0.802 | |||||||||
 | ARHGAP15 | Rho GTPase activating protein 15 (475 aa) |
|
|
0.780 | |||||||||
 | RABIF | RAB interacting factor; Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport (123 aa) |
|
|
0.774 | |||||||||
 | EXOC4 | exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (By similarity) (974 aa) |
|
|
0.764 | |||||||||
 | TBX19 | T-box 19; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters (448 aa) |
|
0.758 | ||||||||||
 | T | T, brachyury homolog (mouse); Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site (435 aa) |
|
0.758 | ||||||||||
 | ARHGAP27 | Rho GTPase activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity) (548 aa) |
|
|
0.751 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
