NDFIP2 protein (Homo sapiens) - STRING network view

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NDFIP2

Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling (336 aa)

Predicted Functional Partners:

NEDD4

0.998

UBC

0.982

NEDD4L

0.970

WWP2

0.949

ITCH

0.930

SLC11A2

0.836

SMURF1

0.834

SOD3

0.748

SOD1

0.748

WWP1

0.685

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ITCH	NDFIP2	ENSP00000363998	ENSP00000218652	itchy E3 ubiquitin protein ligase	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	0.930
ITCH	SLC11A2	ENSP00000363998	ENSP00000378364	itchy E3 ubiquitin protein ligase	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.483
ITCH	UBC	ENSP00000363998	ENSP00000344818	itchy E3 ubiquitin protein ligase	ubiquitin C	0.999
ITCH	WWP1	ENSP00000363998	ENSP00000265428	itchy E3 ubiquitin protein ligase	WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...]	0.901
NDFIP2	ITCH	ENSP00000218652	ENSP00000363998	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	itchy E3 ubiquitin protein ligase	0.930
NDFIP2	NEDD4	ENSP00000218652	ENSP00000345530	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	0.998
NDFIP2	NEDD4L	ENSP00000218652	ENSP00000383199	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	0.970
NDFIP2	SLC11A2	ENSP00000218652	ENSP00000378364	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.836
NDFIP2	SMURF1	ENSP00000218652	ENSP00000354621	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA	0.834
NDFIP2	SOD1	ENSP00000218652	ENSP00000270142	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)	0.748
NDFIP2	SOD3	ENSP00000218652	ENSP00000371554	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	superoxide dismutase 3, extracellular; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen	0.748
NDFIP2	UBC	ENSP00000218652	ENSP00000344818	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	ubiquitin C	0.982
NDFIP2	WWP1	ENSP00000218652	ENSP00000265428	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...]	0.685
NDFIP2	WWP2	ENSP00000218652	ENSP00000348283	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	WW domain containing E3 ubiquitin protein ligase 2	0.949
NEDD4	NDFIP2	ENSP00000345530	ENSP00000218652	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	0.998
NEDD4	SLC11A2	ENSP00000345530	ENSP00000378364	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.770
NEDD4	UBC	ENSP00000345530	ENSP00000344818	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	ubiquitin C	0.999
NEDD4L	NDFIP2	ENSP00000383199	ENSP00000218652	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling	0.970
NEDD4L	SLC11A2	ENSP00000383199	ENSP00000378364	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.779
NEDD4L	SMURF1	ENSP00000383199	ENSP00000354621	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA	0.908

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