node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C2CD4C | ZNF500 | ENSP00000328677 | ENSP00000219478 | C2 calcium-dependent domain containing 4C | zinc finger protein 500; May be involved in transcriptional regulation | 0.477 |
CAPZA2 | ZNF500 | ENSP00000354947 | ENSP00000219478 | capping protein (actin filament) muscle Z-line, alpha 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | zinc finger protein 500; May be involved in transcriptional regulation | 0.505 |
EML5 | TOP3B | ENSP00000451998 | ENSP00000349705 | echinoderm microtubule associated protein like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | topoisomerase (DNA) III beta; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoi [...] | 0.512 |
EML5 | ZNF500 | ENSP00000451998 | ENSP00000219478 | echinoderm microtubule associated protein like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | zinc finger protein 500; May be involved in transcriptional regulation | 0.559 |
FBXL19 | ZNF500 | ENSP00000369666 | ENSP00000219478 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 500; May be involved in transcriptional regulation | 0.501 |
KDM2A | ZNF500 | ENSP00000432786 | ENSP00000219478 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 500; May be involved in transcriptional regulation | 0.501 |
KDM2B | ZNF500 | ENSP00000366271 | ENSP00000219478 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 500; May be involved in transcriptional regulation | 0.501 |
PTPN23 | ZNF500 | ENSP00000265562 | ENSP00000219478 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 500; May be involved in transcriptional regulation | 0.476 |
RANBP2 | ZNF500 | ENSP00000283195 | ENSP00000219478 | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB | zinc finger protein 500; May be involved in transcriptional regulation | 0.465 |
TOP3B | EML5 | ENSP00000349705 | ENSP00000451998 | topoisomerase (DNA) III beta; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoi [...] | echinoderm microtubule associated protein like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.512 |
TOP3B | ZNF500 | ENSP00000349705 | ENSP00000219478 | topoisomerase (DNA) III beta; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoi [...] | zinc finger protein 500; May be involved in transcriptional regulation | 0.671 |
XRN1 | ZNF500 | ENSP00000264951 | ENSP00000219478 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 500; May be involved in transcriptional regulation | 0.543 |
ZNF500 | C2CD4C | ENSP00000219478 | ENSP00000328677 | zinc finger protein 500; May be involved in transcriptional regulation | C2 calcium-dependent domain containing 4C | 0.477 |
ZNF500 | CAPZA2 | ENSP00000219478 | ENSP00000354947 | zinc finger protein 500; May be involved in transcriptional regulation | capping protein (actin filament) muscle Z-line, alpha 2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | 0.505 |
ZNF500 | EML5 | ENSP00000219478 | ENSP00000451998 | zinc finger protein 500; May be involved in transcriptional regulation | echinoderm microtubule associated protein like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic (By similarity) | 0.559 |
ZNF500 | FBXL19 | ENSP00000219478 | ENSP00000369666 | zinc finger protein 500; May be involved in transcriptional regulation | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
ZNF500 | KDM2A | ENSP00000219478 | ENSP00000432786 | zinc finger protein 500; May be involved in transcriptional regulation | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |
ZNF500 | KDM2B | ENSP00000219478 | ENSP00000366271 | zinc finger protein 500; May be involved in transcriptional regulation | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | 0.501 |
ZNF500 | PTPN23 | ENSP00000219478 | ENSP00000265562 | zinc finger protein 500; May be involved in transcriptional regulation | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.476 |
ZNF500 | RANBP2 | ENSP00000219478 | ENSP00000283195 | zinc finger protein 500; May be involved in transcriptional regulation | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB | 0.465 |