node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDH18A1 | CRYM | ENSP00000360268 | ENSP00000219599 | aldehyde dehydrogenase 18 family, member A1 | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | 0.555 |
ALDH18A1 | DECR1 | ENSP00000360268 | ENSP00000220764 | aldehyde dehydrogenase 18 family, member A1 | 2,4-dienoyl CoA reductase 1, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA | 0.472 |
CRYBA1 | CRYBB1 | ENSP00000225387 | ENSP00000215939 | crystallin, beta A1; Crystallins are the dominant structural components of the vertebrate eye lens | crystallin, beta B1; Crystallins are the dominant structural components of the vertebrate eye lens | 0.947 |
CRYBA1 | CRYM | ENSP00000225387 | ENSP00000219599 | crystallin, beta A1; Crystallins are the dominant structural components of the vertebrate eye lens | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | 0.493 |
CRYBA1 | PMM1 | ENSP00000225387 | ENSP00000216259 | crystallin, beta A1; Crystallins are the dominant structural components of the vertebrate eye lens | phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain | 0.493 |
CRYBA1 | SSTR1 | ENSP00000225387 | ENSP00000267377 | crystallin, beta A1; Crystallins are the dominant structural components of the vertebrate eye lens | somatostatin receptor 1; Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins | 0.418 |
CRYBB1 | CRYBA1 | ENSP00000215939 | ENSP00000225387 | crystallin, beta B1; Crystallins are the dominant structural components of the vertebrate eye lens | crystallin, beta A1; Crystallins are the dominant structural components of the vertebrate eye lens | 0.947 |
CRYBB1 | CRYM | ENSP00000215939 | ENSP00000219599 | crystallin, beta B1; Crystallins are the dominant structural components of the vertebrate eye lens | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | 0.587 |
CRYBB1 | PMM1 | ENSP00000215939 | ENSP00000216259 | crystallin, beta B1; Crystallins are the dominant structural components of the vertebrate eye lens | phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain | 0.562 |
CRYBB1 | SSTR1 | ENSP00000215939 | ENSP00000267377 | crystallin, beta B1; Crystallins are the dominant structural components of the vertebrate eye lens | somatostatin receptor 1; Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins | 0.455 |
CRYL1 | CRYM | ENSP00000298248 | ENSP00000219599 | crystallin, lambda 1 | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | 0.585 |
CRYM | ALDH18A1 | ENSP00000219599 | ENSP00000360268 | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | aldehyde dehydrogenase 18 family, member A1 | 0.555 |
CRYM | CRYBA1 | ENSP00000219599 | ENSP00000225387 | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | crystallin, beta A1; Crystallins are the dominant structural components of the vertebrate eye lens | 0.493 |
CRYM | CRYBB1 | ENSP00000219599 | ENSP00000215939 | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | crystallin, beta B1; Crystallins are the dominant structural components of the vertebrate eye lens | 0.587 |
CRYM | CRYL1 | ENSP00000219599 | ENSP00000298248 | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | crystallin, lambda 1 | 0.585 |
CRYM | DECR1 | ENSP00000219599 | ENSP00000220764 | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | 2,4-dienoyl CoA reductase 1, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA | 0.863 |
CRYM | L3HYPDH | ENSP00000219599 | ENSP00000247194 | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | L-3-hydroxyproline dehydratase (trans-); Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it | 0.510 |
CRYM | PLOD2 | ENSP00000219599 | ENSP00000282903 | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links | 0.490 |
CRYM | PMM1 | ENSP00000219599 | ENSP00000216259 | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain | 0.606 |
CRYM | SLC17A8 | ENSP00000219599 | ENSP00000316909 | crystallin, mu; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate | 0.641 |