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SHPK SHPK GK5 GK5 GPD2 GPD2 GK2 GK2 AQP11 AQP11 AQP7 AQP7 AQP9 AQP9 GK GK INS INS CFTR CFTR SLC9A3R1 SLC9A3R1
"AQP9" - aquaporin 9 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
AQP9aquaporin 9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol (295 aa)    
Predicted Functional Partners:
AQP7
aquaporin 7; Forms a channel for water and glycerol (342 aa)
    score_image     score_image score_image score_image 0.909
GK
glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism (553 aa)
score_image     score_image     score_image   0.905
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
        score_image   score_image   0.885
INS
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) (110 aa)
            score_image   0.842
SLC9A3R1
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli ( [...] (358 aa)
            score_image   0.804
GK5
glycerol kinase 5 (putative) (529 aa)
score_image     score_image     score_image   0.791
GK2
glycerol kinase 2; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) (553 aa)
score_image     score_image     score_image   0.791
SHPK
sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism (By similarity) (478 aa)
score_image     score_image     score_image   0.791
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial) (727 aa)
score_image     score_image     score_image   0.739
AQP11
aquaporin 11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity) (271 aa)
            score_image   0.667
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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