node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AQP11 | AQP7 | ENSP00000318770 | ENSP00000297988 | aquaporin 11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity) | aquaporin 7; Forms a channel for water and glycerol | 0.791 |
AQP11 | AQP9 | ENSP00000318770 | ENSP00000219919 | aquaporin 11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity) | aquaporin 9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol | 0.667 |
AQP7 | AQP11 | ENSP00000297988 | ENSP00000318770 | aquaporin 7; Forms a channel for water and glycerol | aquaporin 11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity) | 0.791 |
AQP7 | AQP9 | ENSP00000297988 | ENSP00000219919 | aquaporin 7; Forms a channel for water and glycerol | aquaporin 9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol | 0.909 |
AQP7 | CFTR | ENSP00000297988 | ENSP00000003084 | aquaporin 7; Forms a channel for water and glycerol | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 | 0.867 |
AQP7 | GK | ENSP00000297988 | ENSP00000368226 | aquaporin 7; Forms a channel for water and glycerol | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | 0.908 |
AQP7 | GK2 | ENSP00000297988 | ENSP00000351706 | aquaporin 7; Forms a channel for water and glycerol | glycerol kinase 2; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) | 0.791 |
AQP7 | GK5 | ENSP00000297988 | ENSP00000418001 | aquaporin 7; Forms a channel for water and glycerol | glycerol kinase 5 (putative) | 0.791 |
AQP7 | GPD2 | ENSP00000297988 | ENSP00000308610 | aquaporin 7; Forms a channel for water and glycerol | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.747 |
AQP7 | INS | ENSP00000297988 | ENSP00000250971 | aquaporin 7; Forms a channel for water and glycerol | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.871 |
AQP7 | SHPK | ENSP00000297988 | ENSP00000225519 | aquaporin 7; Forms a channel for water and glycerol | sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism (By similarity) | 0.791 |
AQP7 | SLC9A3R1 | ENSP00000297988 | ENSP00000262613 | aquaporin 7; Forms a channel for water and glycerol | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli ( [...] | 0.618 |
AQP9 | AQP11 | ENSP00000219919 | ENSP00000318770 | aquaporin 9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol | aquaporin 11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes (By similarity) | 0.667 |
AQP9 | AQP7 | ENSP00000219919 | ENSP00000297988 | aquaporin 9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol | aquaporin 7; Forms a channel for water and glycerol | 0.909 |
AQP9 | CFTR | ENSP00000219919 | ENSP00000003084 | aquaporin 9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 | 0.885 |
AQP9 | GK | ENSP00000219919 | ENSP00000368226 | aquaporin 9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol | glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism | 0.905 |
AQP9 | GK2 | ENSP00000219919 | ENSP00000351706 | aquaporin 9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol | glycerol kinase 2; Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) | 0.791 |
AQP9 | GK5 | ENSP00000219919 | ENSP00000418001 | aquaporin 9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol | glycerol kinase 5 (putative) | 0.791 |
AQP9 | GPD2 | ENSP00000219919 | ENSP00000308610 | aquaporin 9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.739 |
AQP9 | INS | ENSP00000219919 | ENSP00000250971 | aquaporin 9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.842 |