node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDNF | EHD4 | ENSP00000414303 | ENSP00000220325 | brain-derived neurotrophic factor | EH-domain containing 4; Plays a role in early endosomal transport | 0.901 |
BDNF | NTRK2 | ENSP00000414303 | ENSP00000277120 | brain-derived neurotrophic factor | neurotrophic tyrosine kinase, receptor, type 2; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin- 4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activat [...] | 0.999 |
BDNF | UBC | ENSP00000414303 | ENSP00000344818 | brain-derived neurotrophic factor | ubiquitin C | 0.409 |
CDH23 | EHD1 | ENSP00000381768 | ENSP00000320516 | cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | 0.505 |
CDH23 | EHD4 | ENSP00000381768 | ENSP00000220325 | cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | EH-domain containing 4; Plays a role in early endosomal transport | 0.919 |
DGKQ | EHD1 | ENSP00000273814 | ENSP00000320516 | diacylglycerol kinase, theta 110kDa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | 0.997 |
DGKQ | EHD4 | ENSP00000273814 | ENSP00000220325 | diacylglycerol kinase, theta 110kDa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity | EH-domain containing 4; Plays a role in early endosomal transport | 0.997 |
EHD1 | CDH23 | ENSP00000320516 | ENSP00000381768 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | 0.505 |
EHD1 | DGKQ | ENSP00000320516 | ENSP00000273814 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | diacylglycerol kinase, theta 110kDa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity | 0.997 |
EHD1 | EHD4 | ENSP00000320516 | ENSP00000220325 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | EH-domain containing 4; Plays a role in early endosomal transport | 0.999 |
EHD1 | NUMB | ENSP00000320516 | ENSP00000347169 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | numb homolog (Drosophila) | 0.873 |
EHD1 | NUMBL | ENSP00000320516 | ENSP00000252891 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | numb homolog (Drosophila)-like; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of [...] | 0.827 |
EHD1 | RAB5A | ENSP00000320516 | ENSP00000273047 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | 0.923 |
EHD1 | UBC | ENSP00000320516 | ENSP00000344818 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | ubiquitin C | 0.812 |
EHD4 | BDNF | ENSP00000220325 | ENSP00000414303 | EH-domain containing 4; Plays a role in early endosomal transport | brain-derived neurotrophic factor | 0.901 |
EHD4 | CDH23 | ENSP00000220325 | ENSP00000381768 | EH-domain containing 4; Plays a role in early endosomal transport | cadherin-related 23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing | 0.919 |
EHD4 | DGKQ | ENSP00000220325 | ENSP00000273814 | EH-domain containing 4; Plays a role in early endosomal transport | diacylglycerol kinase, theta 110kDa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity | 0.997 |
EHD4 | EHD1 | ENSP00000220325 | ENSP00000320516 | EH-domain containing 4; Plays a role in early endosomal transport | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | 0.999 |
EHD4 | NTRK2 | ENSP00000220325 | ENSP00000277120 | EH-domain containing 4; Plays a role in early endosomal transport | neurotrophic tyrosine kinase, receptor, type 2; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin- 4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activat [...] | 0.905 |
EHD4 | NUMB | ENSP00000220325 | ENSP00000347169 | EH-domain containing 4; Plays a role in early endosomal transport | numb homolog (Drosophila) | 0.870 |