| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALB | ASGR1 | ENSP00000295897 | ENSP00000269299 | albumin | asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface | 0.506 |
| ALB | HHEX | ENSP00000295897 | ENSP00000282728 | albumin | hematopoietically expressed homeobox; Recognizes the DNA sequence 5’-ATTAA-3’. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity) | 0.568 |
| ALB | HSPA5 | ENSP00000295897 | ENSP00000324173 | albumin | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.565 |
| ALB | INS | ENSP00000295897 | ENSP00000250971 | albumin | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.982 |
| ALB | LRP2 | ENSP00000295897 | ENSP00000263816 | albumin | low density lipoprotein receptor-related protein 2; Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release | 0.972 |
| ALB | TG | ENSP00000295897 | ENSP00000220616 | albumin | thyroglobulin | 0.824 |
| ALB | TPO | ENSP00000295897 | ENSP00000318820 | albumin | thyroid peroxidase | 0.568 |
| ASGR1 | ALB | ENSP00000269299 | ENSP00000295897 | asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface | albumin | 0.506 |
| ASGR1 | HSPA5 | ENSP00000269299 | ENSP00000324173 | asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | 0.577 |
| ASGR1 | TG | ENSP00000269299 | ENSP00000220616 | asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface | thyroglobulin | 0.927 |
| HHEX | ALB | ENSP00000282728 | ENSP00000295897 | hematopoietically expressed homeobox; Recognizes the DNA sequence 5’-ATTAA-3’. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity) | albumin | 0.568 |
| HHEX | INS | ENSP00000282728 | ENSP00000250971 | hematopoietically expressed homeobox; Recognizes the DNA sequence 5’-ATTAA-3’. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity) | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.516 |
| HHEX | TG | ENSP00000282728 | ENSP00000220616 | hematopoietically expressed homeobox; Recognizes the DNA sequence 5’-ATTAA-3’. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity) | thyroglobulin | 0.859 |
| HSPA5 | ALB | ENSP00000324173 | ENSP00000295897 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | albumin | 0.565 |
| HSPA5 | ASGR1 | ENSP00000324173 | ENSP00000269299 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface | 0.577 |
| HSPA5 | INS | ENSP00000324173 | ENSP00000250971 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.564 |
| HSPA5 | PDIA4 | ENSP00000324173 | ENSP00000286091 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | protein disulfide isomerase family A, member 4 | 0.949 |
| HSPA5 | TG | ENSP00000324173 | ENSP00000220616 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | thyroglobulin | 0.872 |
| HSPA5 | TSHR | ENSP00000324173 | ENSP00000298171 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER | thyroid stimulating hormone receptor | 0.591 |
| INS | ALB | ENSP00000250971 | ENSP00000295897 | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | albumin | 0.982 |
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