GDAP1 protein (Homo sapiens) - STRING network view

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GDAP1

ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission (358 aa)

Predicted Functional Partners:

MPZ

0.870

PMP2

0.860

FIS1

0.784

NDRG1

0.756

FGD4

0.750

SH3TC2

0.749

PMP22

0.749

KIF1B

0.747

MFN2

0.746

SBF2

0.728

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGD4	GDAP1	ENSP00000394487	ENSP00000220822	FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	0.750
FGD4	MPZ	ENSP00000394487	ENSP00000431538	FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)	myelin protein zero; Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae	0.414
FGD4	NDRG1	ENSP00000394487	ENSP00000319977	FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)	N-myc downstream regulated 1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle c [...]	0.742
FGD4	PMP2	ENSP00000394487	ENSP00000256103	FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)	peripheral myelin protein 2; May play a role in lipid transport protein in Schwann cells. May bind cholesterol	0.487
FGD4	SBF2	ENSP00000394487	ENSP00000256190	FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)	SET binding factor 2	0.685
FGD4	SH3TC2	ENSP00000394487	ENSP00000423660	FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)	SH3 domain and tetratricopeptide repeats 2	0.748
FIS1	GDAP1	ENSP00000223136	ENSP00000220822	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	0.784
FIS1	MFN2	ENSP00000223136	ENSP00000235329	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	mitofusin 2; Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation	0.970
GDAP1	FGD4	ENSP00000220822	ENSP00000394487	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity)	0.750
GDAP1	FIS1	ENSP00000220822	ENSP00000223136	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission	0.784
GDAP1	KIF1B	ENSP00000220822	ENSP00000263934	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	kinesin family member 1B	0.747
GDAP1	MFN2	ENSP00000220822	ENSP00000235329	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	mitofusin 2; Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation	0.746
GDAP1	MPZ	ENSP00000220822	ENSP00000431538	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	myelin protein zero; Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae	0.870
GDAP1	NDRG1	ENSP00000220822	ENSP00000319977	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	N-myc downstream regulated 1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle c [...]	0.756
GDAP1	PMP2	ENSP00000220822	ENSP00000256103	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	peripheral myelin protein 2; May play a role in lipid transport protein in Schwann cells. May bind cholesterol	0.860
GDAP1	PMP22	ENSP00000220822	ENSP00000308937	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system	0.749
GDAP1	SBF2	ENSP00000220822	ENSP00000256190	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	SET binding factor 2	0.728
GDAP1	SH3TC2	ENSP00000220822	ENSP00000423660	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	SH3 domain and tetratricopeptide repeats 2	0.749
KIF1B	GDAP1	ENSP00000263934	ENSP00000220822	kinesin family member 1B	ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission	0.747
KIF1B	MFN2	ENSP00000263934	ENSP00000235329	kinesin family member 1B	mitofusin 2; Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation	0.709

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