Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
|
Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
|||||
 | RSPH6A | radial spoke head 6 homolog A (Chlamydomonas) (717 aa) | ||||||||||||
Predicted Functional Partners:
| ||||||||||||||
 | ENSG00000268434 | Uncharacterized protein (132 aa) |
 |
0.889 | ||||||||||
 | DNAAF3 | dynein, axonemal, assembly factor 3; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia (588 aa) |
|
0.800 | ||||||||||
 | RSPH9 | radial spoke head 9 homolog (Chlamydomonas); Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules (306 aa) |
|
|
0.768 | |||||||||
 | DMWD | dystrophia myotonica, WD repeat containing; Could have a regulatory function in meiosis (674 aa) |
|
0.759 | ||||||||||
 | PRKAG3 | protein kinase, AMP-activated, gamma 3 non-catalytic subunit; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Al [...] (489 aa) |
|
0.604 | ||||||||||
 | TEKT4 | tektin 4; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity) (435 aa) |
|
|
0.588 | |||||||||
 | LARS | leucyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs (1176 aa) |
|
0.572 | ||||||||||
 | ODF3L1 | outer dense fiber of sperm tails 3-like 1 (274 aa) |
|
0.539 | ||||||||||
 | TMX1 | thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions (280 aa) |
|
0.527 | ||||||||||
 | VARS | valyl-tRNA synthetase (1264 aa) |
|
0.513 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
Share
