| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHM | RAB3D | ENSP00000350386 | ENSP00000222120 | choroideremia (Rab escort protein 1); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | 0.714 |
| DOC2B | RAB3D | ENSP00000343665 | ENSP00000222120 | double C2-like domains, beta; Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes [...] | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | 0.779 |
| DYNLT1 | RAB3D | ENSP00000356056 | ENSP00000222120 | dynein, light chain, Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic [...] | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | 0.887 |
| LRPAP1 | RAB35 | ENSP00000421922 | ENSP00000229340 | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | RAB35, member RAS oncogene family; In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge | 0.589 |
| LRPAP1 | RAB3D | ENSP00000421922 | ENSP00000222120 | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | 0.747 |
| RAB35 | LRPAP1 | ENSP00000229340 | ENSP00000421922 | RAB35, member RAS oncogene family; In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | 0.589 |
| RAB35 | RAB3D | ENSP00000229340 | ENSP00000222120 | RAB35, member RAS oncogene family; In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | 0.701 |
| RAB3D | CHM | ENSP00000222120 | ENSP00000350386 | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | choroideremia (Rab escort protein 1); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation | 0.714 |
| RAB3D | DOC2B | ENSP00000222120 | ENSP00000343665 | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | double C2-like domains, beta; Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes [...] | 0.779 |
| RAB3D | DYNLT1 | ENSP00000222120 | ENSP00000356056 | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | dynein, light chain, Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic [...] | 0.887 |
| RAB3D | LRPAP1 | ENSP00000222120 | ENSP00000421922 | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | 0.747 |
| RAB3D | RAB35 | ENSP00000222120 | ENSP00000229340 | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | RAB35, member RAS oncogene family; In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge | 0.701 |
| RAB3D | RAB3IP | ENSP00000222120 | ENSP00000447300 | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | RAB3A interacting protein (rabin3) | 0.910 |
| RAB3D | RIMS2 | ENSP00000222120 | ENSP00000384892 | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | regulating synaptic membrane exocytosis 2; Rab effector involved in exocytosis. May act as scaffold protein | 0.726 |
| RAB3D | RPH3A | ENSP00000222120 | ENSP00000374036 | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | rabphilin 3A homolog (mouse); Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity) | 0.941 |
| RAB3D | RPH3AL | ENSP00000222120 | ENSP00000328977 | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | rabphilin 3A-like (without C2 domains); Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells | 0.835 |
| RAB3D | STX2 | ENSP00000222120 | ENSP00000376178 | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm | 0.685 |
| RAB3IP | RAB3D | ENSP00000447300 | ENSP00000222120 | RAB3A interacting protein (rabin3) | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | 0.910 |
| RAB3IP | RPH3A | ENSP00000447300 | ENSP00000374036 | RAB3A interacting protein (rabin3) | rabphilin 3A homolog (mouse); Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity) | 0.406 |
| RIMS2 | RAB3D | ENSP00000384892 | ENSP00000222120 | regulating synaptic membrane exocytosis 2; Rab effector involved in exocytosis. May act as scaffold protein | RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) | 0.726 |
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