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KLF1 KLF1 DFFA DFFA RUVBL2 RUVBL2 DFFB DFFB RUVBL1 RUVBL1 DNASE2 DNASE2 OPA1 OPA1 DNASE1 DNASE1 RRM1 RRM1 DNASE1L2 DNASE1L2 DNAJB11 DNAJB11
"DNASE2" - deoxyribonuclease II, lysosomal in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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DNASE2deoxyribonuclease II, lysosomal; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells (360 aa)    
Predicted Functional Partners:
RRM1
ribonucleotide reductase M1; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) (792 aa)
        score_image       0.988
DNAJB11
DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (358 aa)
        score_image       0.971
KLF1
Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...] (362 aa)
            score_image   0.790
DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology (338 aa)
            score_image   0.763
DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide; Inhibitor of the caspase-activated DNase (DFF40) (331 aa)
            score_image   0.751
DNASE1L2
deoxyribonuclease I-like 2 (299 aa)
            score_image   0.678
OPA1
optic atrophy 1 (autosomal dominant); Dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (997 aa)
        score_image   score_image   0.675
DNASE1
deoxyribonuclease I; Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity) (282 aa)
            score_image   0.665
RUVBL2
RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (463 aa)
        score_image       0.615
RUVBL1
RuvB-like 1 (E. coli); May be able to bind plasminogen at cell surface and enhance plasminogen activation (456 aa)
        score_image       0.615
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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