node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARRDC2 | BAG3 | ENSP00000222250 | ENSP00000358081 | arrestin domain containing 2 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | 0.552 |
ARRDC2 | GAS7 | ENSP00000222250 | ENSP00000407552 | arrestin domain containing 2 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | 0.598 |
ARRDC2 | HECW1 | ENSP00000222250 | ENSP00000379228 | arrestin domain containing 2 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS | 0.552 |
ARRDC2 | ITCH | ENSP00000222250 | ENSP00000363998 | arrestin domain containing 2 | itchy E3 ubiquitin protein ligase | 0.552 |
ARRDC2 | KPNA6 | ENSP00000222250 | ENSP00000362728 | arrestin domain containing 2 | karyopherin alpha 6 (importin alpha 7); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] | 0.667 |
ARRDC2 | NEDD4 | ENSP00000222250 | ENSP00000345530 | arrestin domain containing 2 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.618 |
ARRDC2 | NEDD4L | ENSP00000222250 | ENSP00000383199 | arrestin domain containing 2 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.552 |
ARRDC2 | TXN | ENSP00000222250 | ENSP00000363641 | arrestin domain containing 2 | thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...] | 0.638 |
ARRDC2 | WWP1 | ENSP00000222250 | ENSP00000265428 | arrestin domain containing 2 | WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...] | 0.827 |
ARRDC2 | WWP2 | ENSP00000222250 | ENSP00000348283 | arrestin domain containing 2 | WW domain containing E3 ubiquitin protein ligase 2 | 0.585 |
BAG3 | ARRDC2 | ENSP00000358081 | ENSP00000222250 | BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity | arrestin domain containing 2 | 0.552 |
GAS7 | ARRDC2 | ENSP00000407552 | ENSP00000222250 | growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons | arrestin domain containing 2 | 0.598 |
HECW1 | ARRDC2 | ENSP00000379228 | ENSP00000222250 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS | arrestin domain containing 2 | 0.552 |
ITCH | ARRDC2 | ENSP00000363998 | ENSP00000222250 | itchy E3 ubiquitin protein ligase | arrestin domain containing 2 | 0.552 |
ITCH | WWP1 | ENSP00000363998 | ENSP00000265428 | itchy E3 ubiquitin protein ligase | WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...] | 0.901 |
KPNA6 | ARRDC2 | ENSP00000362728 | ENSP00000222250 | karyopherin alpha 6 (importin alpha 7); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] | arrestin domain containing 2 | 0.667 |
NEDD4 | ARRDC2 | ENSP00000345530 | ENSP00000222250 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | arrestin domain containing 2 | 0.618 |
NEDD4L | ARRDC2 | ENSP00000383199 | ENSP00000222250 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | arrestin domain containing 2 | 0.552 |
NEDD4L | WWP1 | ENSP00000383199 | ENSP00000265428 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...] | 0.929 |
TXN | ARRDC2 | ENSP00000363641 | ENSP00000222250 | thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...] | arrestin domain containing 2 | 0.638 |