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RIMS1 RIMS1 SLC17A7 SLC17A7 SYT1 SYT1 VAMP2 VAMP2 UNC13B UNC13B RAB3A RAB3A RIMS2 RIMS2 RAB3IP RAB3IP SYN1 SYN1 RPH3A RPH3A SYTL4 SYTL4
RAB3A, member RAS oncogene family in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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query proteins and first shell of interactors
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second shell of interactors
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RAB3ARAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (220 aa)    
Predicted Functional Partners:
RPH3A
rabphilin 3A homolog (mouse); Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity) (694 aa)
        score_image   score_image   0.998
RIMS1
regulating synaptic membrane exocytosis 1 (1692 aa)
        score_image score_image score_image   0.998
RIMS2
regulating synaptic membrane exocytosis 2; Rab effector involved in exocytosis. May act as scaffold protein (1349 aa)
      score_image score_image score_image score_image   0.995
RAB3IP
RAB3A interacting protein (rabin3) (476 aa)
        score_image   score_image   0.982
SYT1
synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 (422 aa)
      score_image   score_image score_image   0.980
SYTL4
synaptotagmin-like 4; Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity) (671 aa)
      score_image score_image   score_image   0.976
VAMP2
vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane (116 aa)
          score_image score_image   0.975
UNC13B
unc-13 homolog B (C. elegans); Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity) (1591 aa)
          score_image score_image   0.974
SYN1
synapsin I; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level (705 aa)
      score_image     score_image   0.939
SLC17A7
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate (560 aa)
          score_image score_image   0.932
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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