TMEM147 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TMEM147

transmembrane protein 147 (224 aa)

Predicted Functional Partners:

NCLN

0.979

NOMO2

0.977

DUSP19

0.844

NOMO1

0.760

PFDN5

0.716

UBC

0.620

ABHD16A

0.615

GUF1

0.609

GMFG

0.563

GMFB

0.563

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABHD16A	TMEM147	ENSP00000379282	ENSP00000222284	abhydrolase domain containing 16A	transmembrane protein 147	0.615
DUSP19	TMEM147	ENSP00000346160	ENSP00000222284	dual specificity phosphatase 19; Has a dual specificity toward Ser/Thr and Tyr-containing proteins	transmembrane protein 147	0.844
GMFB	TMEM147	ENSP00000350757	ENSP00000222284	glia maturation factor, beta; This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells	transmembrane protein 147	0.563
GMFB	UBC	ENSP00000350757	ENSP00000344818	glia maturation factor, beta; This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells	ubiquitin C	0.894
GMFG	TMEM147	ENSP00000472249	ENSP00000222284	glia maturation factor, gamma	transmembrane protein 147	0.563
GMFG	UBC	ENSP00000472249	ENSP00000344818	glia maturation factor, gamma	ubiquitin C	0.894
GUF1	TMEM147	ENSP00000281543	ENSP00000222284	GUF1 GTPase homolog (S. cerevisiae); Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity)	transmembrane protein 147	0.609
NCLN	NOMO1	ENSP00000246117	ENSP00000287667	nicalin	NODAL modulator 1; May antagonize Nodal signaling (By similarity)	0.937
NCLN	NOMO2	ENSP00000246117	ENSP00000370883	nicalin	NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity)	0.937
NCLN	TMEM147	ENSP00000246117	ENSP00000222284	nicalin	transmembrane protein 147	0.979
NCLN	UBC	ENSP00000246117	ENSP00000344818	nicalin	ubiquitin C	0.938
NOMO1	NCLN	ENSP00000287667	ENSP00000246117	NODAL modulator 1; May antagonize Nodal signaling (By similarity)	nicalin	0.937
NOMO1	TMEM147	ENSP00000287667	ENSP00000222284	NODAL modulator 1; May antagonize Nodal signaling (By similarity)	transmembrane protein 147	0.760
NOMO1	UBC	ENSP00000287667	ENSP00000344818	NODAL modulator 1; May antagonize Nodal signaling (By similarity)	ubiquitin C	0.921
NOMO2	NCLN	ENSP00000370883	ENSP00000246117	NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity)	nicalin	0.937
NOMO2	TMEM147	ENSP00000370883	ENSP00000222284	NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity)	transmembrane protein 147	0.977
NOMO2	UBC	ENSP00000370883	ENSP00000344818	NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity)	ubiquitin C	0.942
PFDN5	TMEM147	ENSP00000334188	ENSP00000222284	prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC	transmembrane protein 147	0.716
PFDN5	UBC	ENSP00000334188	ENSP00000344818	prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC	ubiquitin C	0.940
TMEM147	ABHD16A	ENSP00000222284	ENSP00000379282	transmembrane protein 147	abhydrolase domain containing 16A	0.615

page 1 of 2

Experiments

Fusion

Textmining

Cooccurrence

Coexpression

Neighborhood

Databases

© STRING Consortium 2017

Credits

Access

Info

About