| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATOH8 | BMP6 | ENSP00000304676 | ENSP00000283147 | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.703 |
| ATOH8 | GDF15 | ENSP00000304676 | ENSP00000252809 | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | growth differentiation factor 15 | 0.415 |
| ATOH8 | HAMP | ENSP00000304676 | ENSP00000222304 | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | 0.854 |
| BMP6 | ATOH8 | ENSP00000283147 | ENSP00000304676 | bone morphogenetic protein 6; Induces cartilage and bone formation | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | 0.703 |
| BMP6 | HAMP | ENSP00000283147 | ENSP00000222304 | bone morphogenetic protein 6; Induces cartilage and bone formation | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | 0.893 |
| BMP6 | IL6 | ENSP00000283147 | ENSP00000258743 | bone morphogenetic protein 6; Induces cartilage and bone formation | interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] | 0.874 |
| CREB3L3 | GDF15 | ENSP00000078445 | ENSP00000252809 | cAMP responsive element binding protein 3-like 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression | growth differentiation factor 15 | 0.561 |
| CREB3L3 | HAMP | ENSP00000078445 | ENSP00000222304 | cAMP responsive element binding protein 3-like 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | 0.894 |
| GDF15 | ATOH8 | ENSP00000252809 | ENSP00000304676 | growth differentiation factor 15 | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | 0.415 |
| GDF15 | CREB3L3 | ENSP00000252809 | ENSP00000078445 | growth differentiation factor 15 | cAMP responsive element binding protein 3-like 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression | 0.561 |
| GDF15 | HAMP | ENSP00000252809 | ENSP00000222304 | growth differentiation factor 15 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | 0.865 |
| GDF15 | IL6 | ENSP00000252809 | ENSP00000258743 | growth differentiation factor 15 | interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] | 0.874 |
| HAMP | ATOH8 | ENSP00000222304 | ENSP00000304676 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | atonal homolog 8 (Drosophila); Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation (By similarity) | 0.854 |
| HAMP | BMP6 | ENSP00000222304 | ENSP00000283147 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | bone morphogenetic protein 6; Induces cartilage and bone formation | 0.893 |
| HAMP | CREB3L3 | ENSP00000222304 | ENSP00000078445 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | cAMP responsive element binding protein 3-like 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression | 0.894 |
| HAMP | GDF15 | ENSP00000222304 | ENSP00000252809 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | growth differentiation factor 15 | 0.865 |
| HAMP | HFE | ENSP00000222304 | ENSP00000417404 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | hemochromatosis | 0.953 |
| HAMP | IL6 | ENSP00000222304 | ENSP00000258743 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] | 0.859 |
| HAMP | NAAA | ENSP00000222304 | ENSP00000286733 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | N-acylethanolamine acid amidase; Degrades bioactive fatty acid amides to their corresponding acids, with the following preference- N- palmitoylethanolamine > N-myristoylethanolamine > N- lauroylethanolamine = N-stearoylethanolamine > N- arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N- lauroylsphingosine and N-palmitoylsphingosine | 0.866 |
| HAMP | SLC11A2 | ENSP00000222304 | ENSP00000378364 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 0.918 |
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