node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BLOC1S1 | BLOC1S3 | ENSP00000447537 | ENSP00000393840 | biogenesis of lysosomal organelles complex-1, subunit 1; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May negatively regulate aerobic respiration through mitochondrial prot [...] | biogenesis of lysosomal organelles complex-1, subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking | 0.996 |
BLOC1S1 | KXD1 | ENSP00000447537 | ENSP00000222307 | biogenesis of lysosomal organelles complex-1, subunit 1; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May negatively regulate aerobic respiration through mitochondrial prot [...] | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | 0.781 |
BLOC1S3 | BLOC1S1 | ENSP00000393840 | ENSP00000447537 | biogenesis of lysosomal organelles complex-1, subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking | biogenesis of lysosomal organelles complex-1, subunit 1; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May negatively regulate aerobic respiration through mitochondrial prot [...] | 0.996 |
BLOC1S3 | KXD1 | ENSP00000393840 | ENSP00000222307 | biogenesis of lysosomal organelles complex-1, subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | 0.594 |
C17orf59 | KXD1 | ENSP00000373669 | ENSP00000222307 | chromosome 17 open reading frame 59 | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | 0.584 |
C17orf59 | LRRC45 | ENSP00000373669 | ENSP00000306760 | chromosome 17 open reading frame 59 | leucine rich repeat containing 45 | 0.512 |
GABARAPL1 | KXD1 | ENSP00000266458 | ENSP00000222307 | GABA(A) receptor-associated protein like 1; Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | 0.689 |
GABARAPL1 | MAP1LC3A | ENSP00000266458 | ENSP00000363970 | GABA(A) receptor-associated protein like 1; Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.635 |
KXD1 | BLOC1S1 | ENSP00000222307 | ENSP00000447537 | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | biogenesis of lysosomal organelles complex-1, subunit 1; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May negatively regulate aerobic respiration through mitochondrial prot [...] | 0.781 |
KXD1 | BLOC1S3 | ENSP00000222307 | ENSP00000393840 | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | biogenesis of lysosomal organelles complex-1, subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking | 0.594 |
KXD1 | C17orf59 | ENSP00000222307 | ENSP00000373669 | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | chromosome 17 open reading frame 59 | 0.584 |
KXD1 | GABARAPL1 | ENSP00000222307 | ENSP00000266458 | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | GABA(A) receptor-associated protein like 1; Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles | 0.689 |
KXD1 | LRRC45 | ENSP00000222307 | ENSP00000306760 | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | leucine rich repeat containing 45 | 0.597 |
KXD1 | MAP1LC3A | ENSP00000222307 | ENSP00000363970 | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.594 |
KXD1 | MAP1LC3B | ENSP00000222307 | ENSP00000268607 | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | microtubule-associated protein 1 light chain 3 beta; Involved in formation of autophagosomal vacuoles (autophagosomes) | 0.594 |
KXD1 | MCRS1 | ENSP00000222307 | ENSP00000349640 | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity | 0.692 |
KXD1 | MYH7 | ENSP00000222307 | ENSP00000347507 | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | myosin, heavy chain 7, cardiac muscle, beta | 0.597 |
KXD1 | RUVBL2 | ENSP00000222307 | ENSP00000473172 | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | RuvB-like 2 (E. coli); Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5’ to 3’) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity | 0.692 |
LRRC45 | C17orf59 | ENSP00000306760 | ENSP00000373669 | leucine rich repeat containing 45 | chromosome 17 open reading frame 59 | 0.512 |
LRRC45 | KXD1 | ENSP00000306760 | ENSP00000222307 | leucine rich repeat containing 45 | KxDL motif containing 1; Involved in endosomal cargo sorting (By similarity) | 0.597 |