| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKNA | CPA4 | ENSP00000303769 | ENSP00000222482 | AT-hook transcription factor | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | 0.459 |
| ATP6V0D1 | ATP6V0D2 | ENSP00000290949 | ENSP00000285393 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity) | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity) | 0.901 |
| ATP6V0D1 | CPA4 | ENSP00000290949 | ENSP00000222482 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity) | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | 0.567 |
| ATP6V0D2 | ATP6V0D1 | ENSP00000285393 | ENSP00000290949 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity) | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity) | 0.901 |
| ATP6V0D2 | CPA4 | ENSP00000285393 | ENSP00000222482 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity) | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | 0.567 |
| CMA1 | CPA4 | ENSP00000250378 | ENSP00000222482 | chymase 1, mast cell; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | 0.565 |
| CPA4 | AKNA | ENSP00000222482 | ENSP00000303769 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | AT-hook transcription factor | 0.459 |
| CPA4 | ATP6V0D1 | ENSP00000222482 | ENSP00000290949 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity) | 0.567 |
| CPA4 | ATP6V0D2 | ENSP00000222482 | ENSP00000285393 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity) | 0.567 |
| CPA4 | CMA1 | ENSP00000222482 | ENSP00000250378 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | chymase 1, mast cell; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion | 0.565 |
| CPA4 | DFFB | ENSP00000222482 | ENSP00000367454 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology | 0.519 |
| CPA4 | HAPLN2 | ENSP00000222482 | ENSP00000255039 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | 0.485 |
| CPA4 | LXN | ENSP00000222482 | ENSP00000264265 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | 0.998 |
| CPA4 | POR | ENSP00000222482 | ENSP00000419970 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | P450 (cytochrome) oxidoreductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5 | 0.610 |
| CPA4 | SLC9B1 | ENSP00000222482 | ENSP00000296422 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 | 0.540 |
| CPA4 | SLC9B2 | ENSP00000222482 | ENSP00000354574 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2; Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity) | 0.540 |
| DFFB | CPA4 | ENSP00000367454 | ENSP00000222482 | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase); Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | 0.519 |
| HAPLN2 | CPA4 | ENSP00000255039 | ENSP00000222482 | hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity) | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | 0.485 |
| LXN | CPA4 | ENSP00000264265 | ENSP00000222482 | latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | 0.998 |
| POR | CPA4 | ENSP00000419970 | ENSP00000222482 | P450 (cytochrome) oxidoreductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | 0.610 |
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