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ENSG00000262633 ENSG00000262633 GOSR2 GOSR2 USO1 USO1 SCFD1 SCFD1 SEC22C SEC22C STX5 STX5 SEC22A SEC22A YKT6 YKT6 BET1 BET1 GOSR1 GOSR1 VAMP7 VAMP7
"BET1" - blocked early in transport 1 homolog (S. cerevisiae) in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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experimentally determined
Predicted Interactions
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[Homology]
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BET1blocked early in transport 1 homolog (S. cerevisiae); Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By similarity) (118 aa)    
Predicted Functional Partners:
STX5
syntaxin 5; Mediates endoplasmic reticulum to Golgi transport (By similarity) (355 aa)
        score_image score_image score_image   0.999
ENSG00000262633
Golgi SNAP receptor complex member 2; Uncharacterized protein (232 aa)
      score_image score_image score_image score_image   0.991
GOSR1
golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an impor [...] (250 aa)
        score_image   score_image   0.989
GOSR2
golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network (213 aa)
      score_image score_image   score_image   0.977
SCFD1
sec1 family domain containing 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity) (642 aa)
      score_image score_image   score_image   0.977
YKT6
YKT6 v-SNARE homolog (S. cerevisiae); Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity (198 aa)
        score_image   score_image   0.974
SEC22A
SEC22 vesicle trafficking protein homolog A (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (By similarity) (307 aa)
        score_image   score_image   0.970
USO1
USO1 vesicle docking protein homolog (yeast); General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity (By similarity) (971 aa)
        score_image   score_image   0.967
SEC22C
SEC22 vesicle trafficking protein homolog C (S. cerevisiae); May be involved in vesicle transport between the ER and the Golgi complex (303 aa)
        score_image   score_image   0.960
VAMP7
vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (260 aa)
        score_image   score_image   0.946
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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