node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | APOE | ENSP00000295897 | ENSP00000252486 | albumin | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | 0.918 |
ALB | MTHFR | ENSP00000295897 | ENSP00000365775 | albumin | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.505 |
ALB | PON2 | ENSP00000295897 | ENSP00000222572 | albumin | paraoxonase 2 | 0.560 |
ALB | RAP1A | ENSP00000295897 | ENSP00000348786 | albumin | RAP1A, member of RAS oncogene family; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner | 0.420 |
ALB | RHOA | ENSP00000295897 | ENSP00000400175 | albumin | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.700 |
ALB | UBC | ENSP00000295897 | ENSP00000344818 | albumin | ubiquitin C | 0.905 |
APOE | ALB | ENSP00000252486 | ENSP00000295897 | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | albumin | 0.918 |
APOE | MTHFR | ENSP00000252486 | ENSP00000365775 | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | 0.720 |
APOE | PON2 | ENSP00000252486 | ENSP00000222572 | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | paraoxonase 2 | 0.499 |
APOE | RHOA | ENSP00000252486 | ENSP00000400175 | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.472 |
APOE | UBC | ENSP00000252486 | ENSP00000344818 | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | ubiquitin C | 0.628 |
C5orf48 | PON2 | ENSP00000349669 | ENSP00000222572 | chromosome 5 open reading frame 48 | paraoxonase 2 | 0.440 |
DHX40 | PON2 | ENSP00000251241 | ENSP00000222572 | DEAH (Asp-Glu-Ala-His) box polypeptide 40; Probable ATP-dependent RNA helicase (By similarity) | paraoxonase 2 | 0.758 |
DHX40 | UBC | ENSP00000251241 | ENSP00000344818 | DEAH (Asp-Glu-Ala-His) box polypeptide 40; Probable ATP-dependent RNA helicase (By similarity) | ubiquitin C | 0.812 |
HTR2A | PON2 | ENSP00000367959 | ENSP00000222572 | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production | paraoxonase 2 | 0.572 |
MTHFR | ALB | ENSP00000365775 | ENSP00000295897 | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | albumin | 0.505 |
MTHFR | APOE | ENSP00000365775 | ENSP00000252486 | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | 0.720 |
MTHFR | PON2 | ENSP00000365775 | ENSP00000222572 | methylenetetrahydrofolate reductase (NAD(P)H); Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine | paraoxonase 2 | 0.500 |
PON2 | ALB | ENSP00000222572 | ENSP00000295897 | paraoxonase 2 | albumin | 0.560 |
PON2 | APOE | ENSP00000222572 | ENSP00000252486 | paraoxonase 2 | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | 0.499 |