| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAD | CPS1 | ENSP00000264705 | ENSP00000402608 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | 0.999 |
| CAD | MPP6 | ENSP00000264705 | ENSP00000222644 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) | 0.850 |
| CAD | POLR2F | ENSP00000264705 | ENSP00000403852 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | polymerase (RNA) II (DNA directed) polypeptide F; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp ele [...] | 0.646 |
| CAD | STYK1 | ENSP00000264705 | ENSP00000075503 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | serine/threonine/tyrosine kinase 1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3’-kinases (PI3K) pathways (By similarity) | 0.598 |
| CAD | UMPS | ENSP00000264705 | ENSP00000232607 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | uridine monophosphate synthetase | 0.998 |
| CADM1 | MPP6 | ENSP00000395359 | ENSP00000222644 | cell adhesion molecule 1; Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachme [...] | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) | 0.918 |
| CPS1 | CAD | ENSP00000402608 | ENSP00000264705 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.999 |
| CPS1 | MPP6 | ENSP00000402608 | ENSP00000222644 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) | 0.760 |
| CPS1 | POLR2F | ENSP00000402608 | ENSP00000403852 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | polymerase (RNA) II (DNA directed) polypeptide F; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp ele [...] | 0.637 |
| CPS1 | STYK1 | ENSP00000402608 | ENSP00000075503 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | serine/threonine/tyrosine kinase 1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3’-kinases (PI3K) pathways (By similarity) | 0.436 |
| CPS1 | UMPS | ENSP00000402608 | ENSP00000232607 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | uridine monophosphate synthetase | 0.995 |
| EPB41L2 | LIN7A | ENSP00000338481 | ENSP00000447488 | erythrocyte membrane protein band 4.1-like 2 | lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | 0.403 |
| EPB41L2 | MPP6 | ENSP00000338481 | ENSP00000222644 | erythrocyte membrane protein band 4.1-like 2 | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) | 0.854 |
| LIN7A | EPB41L2 | ENSP00000447488 | ENSP00000338481 | lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | erythrocyte membrane protein band 4.1-like 2 | 0.403 |
| LIN7A | MPP6 | ENSP00000447488 | ENSP00000222644 | lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) | 0.980 |
| LIN7A | STYK1 | ENSP00000447488 | ENSP00000075503 | lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | serine/threonine/tyrosine kinase 1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3’-kinases (PI3K) pathways (By similarity) | 0.608 |
| LIN7B | MPP6 | ENSP00000221459 | ENSP00000222644 | lin-7 homolog B (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) | 0.879 |
| LIN7C | MPP6 | ENSP00000278193 | ENSP00000222644 | lin-7 homolog C (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...] | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) | 0.884 |
| MPP6 | CAD | ENSP00000222644 | ENSP00000264705 | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.850 |
| MPP6 | CADM1 | ENSP00000222644 | ENSP00000395359 | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) | cell adhesion molecule 1; Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachme [...] | 0.918 |
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