node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CPLX1 | ENSG00000263620 | ENSP00000305613 | ENSP00000464383 | complexin 1; Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity) | Uncharacterized protein | 0.796 |
CPLX1 | SNAP25 | ENSP00000305613 | ENSP00000254976 | complexin 1; Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity) | synaptosomal-associated protein, 25kDa | 0.999 |
CPLX1 | STX1A | ENSP00000305613 | ENSP00000222812 | complexin 1; Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity) | syntaxin 1A (brain) | 0.929 |
CPLX1 | SYT1 | ENSP00000305613 | ENSP00000261205 | complexin 1; Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity) | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.977 |
CPLX1 | VAMP1 | ENSP00000305613 | ENSP00000379602 | complexin 1; Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity) | vesicle-associated membrane protein 1 (synaptobrevin 1); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.562 |
CPLX1 | VAMP2 | ENSP00000305613 | ENSP00000314214 | complexin 1; Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity) | vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane | 0.998 |
ENSG00000263620 | CPLX1 | ENSP00000464383 | ENSP00000305613 | Uncharacterized protein | complexin 1; Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity) | 0.796 |
ENSG00000263620 | SNAP25 | ENSP00000464383 | ENSP00000254976 | Uncharacterized protein | synaptosomal-associated protein, 25kDa | 0.927 |
ENSG00000263620 | STX1A | ENSP00000464383 | ENSP00000222812 | Uncharacterized protein | syntaxin 1A (brain) | 0.979 |
ENSG00000263620 | STX8 | ENSP00000464383 | ENSP00000305255 | Uncharacterized protein | syntaxin 8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER | 0.753 |
ENSG00000263620 | STXBP1 | ENSP00000464383 | ENSP00000362399 | Uncharacterized protein | syntaxin binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1-1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions | 0.984 |
ENSG00000263620 | STXBP2 | ENSP00000464383 | ENSP00000221283 | Uncharacterized protein | syntaxin binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N- ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells | 0.881 |
ENSG00000263620 | STXBP5 | ENSP00000464383 | ENSP00000321826 | Uncharacterized protein | syntaxin binding protein 5 (tomosyn); Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity) | 0.517 |
ENSG00000263620 | SYT1 | ENSP00000464383 | ENSP00000261205 | Uncharacterized protein | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.907 |
SNAP25 | CPLX1 | ENSP00000254976 | ENSP00000305613 | synaptosomal-associated protein, 25kDa | complexin 1; Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity) | 0.999 |
SNAP25 | ENSG00000263620 | ENSP00000254976 | ENSP00000464383 | synaptosomal-associated protein, 25kDa | Uncharacterized protein | 0.927 |
SNAP25 | STX1A | ENSP00000254976 | ENSP00000222812 | synaptosomal-associated protein, 25kDa | syntaxin 1A (brain) | 0.929 |
SNAP25 | STX8 | ENSP00000254976 | ENSP00000305255 | synaptosomal-associated protein, 25kDa | syntaxin 8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER | 0.838 |
SNAP25 | STXBP1 | ENSP00000254976 | ENSP00000362399 | synaptosomal-associated protein, 25kDa | syntaxin binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1-1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions | 0.974 |
SNAP25 | STXBP2 | ENSP00000254976 | ENSP00000221283 | synaptosomal-associated protein, 25kDa | syntaxin binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N- ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells | 0.480 |