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CD44 CD44 HAS1 HAS1 HAS3 HAS3 HAS2 HAS2 ADAM2 ADAM2 GRM8 GRM8 HYAL4 HYAL4 ARSB ARSB CFTR CFTR IDUA IDUA SLC14A2 SLC14A2
"HYAL4" - hyaluronoglucosaminidase 4 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
HYAL4hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide (481 aa)    
Predicted Functional Partners:
ARSB
arylsulfatase B (533 aa)
          score_image score_image   0.901
IDUA
iduronidase, alpha-L- (653 aa)
          score_image score_image   0.900
GRM8
glutamate receptor, metabotropic 8 (908 aa)
            score_image   0.668
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
            score_image   0.560
HAS3
hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis (553 aa)
            score_image   0.549
HAS2
hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis (552 aa)
            score_image   0.500
HAS1
hyaluronan synthase 1; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate (578 aa)
            score_image   0.491
CD44
CD44 molecule (Indian blood group) (742 aa)
            score_image   0.488
ADAM2
ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (735 aa)
            score_image   0.474
SLC14A2
solute carrier family 14 (urea transporter), member 2; Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism (920 aa)
            score_image   0.411
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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