node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAM2 | HYAL4 | ENSP00000265708 | ENSP00000223026 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide | 0.474 |
ARSB | HYAL4 | ENSP00000264914 | ENSP00000223026 | arylsulfatase B | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide | 0.901 |
ARSB | IDUA | ENSP00000264914 | ENSP00000247933 | arylsulfatase B | iduronidase, alpha-L- | 0.933 |
CD44 | HAS1 | ENSP00000398632 | ENSP00000222115 | CD44 molecule (Indian blood group) | hyaluronan synthase 1; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate | 0.703 |
CD44 | HAS2 | ENSP00000398632 | ENSP00000306991 | CD44 molecule (Indian blood group) | hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.723 |
CD44 | HAS3 | ENSP00000398632 | ENSP00000304440 | CD44 molecule (Indian blood group) | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.717 |
CD44 | HYAL4 | ENSP00000398632 | ENSP00000223026 | CD44 molecule (Indian blood group) | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide | 0.488 |
CFTR | HYAL4 | ENSP00000003084 | ENSP00000223026 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide | 0.560 |
GRM8 | HYAL4 | ENSP00000344173 | ENSP00000223026 | glutamate receptor, metabotropic 8 | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide | 0.668 |
HAS1 | CD44 | ENSP00000222115 | ENSP00000398632 | hyaluronan synthase 1; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate | CD44 molecule (Indian blood group) | 0.703 |
HAS1 | HYAL4 | ENSP00000222115 | ENSP00000223026 | hyaluronan synthase 1; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide | 0.491 |
HAS2 | CD44 | ENSP00000306991 | ENSP00000398632 | hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | CD44 molecule (Indian blood group) | 0.723 |
HAS2 | HAS3 | ENSP00000306991 | ENSP00000304440 | hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.587 |
HAS2 | HYAL4 | ENSP00000306991 | ENSP00000223026 | hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide | 0.500 |
HAS3 | CD44 | ENSP00000304440 | ENSP00000398632 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | CD44 molecule (Indian blood group) | 0.717 |
HAS3 | HAS2 | ENSP00000304440 | ENSP00000306991 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | hyaluronan synthase 2; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | 0.587 |
HAS3 | HYAL4 | ENSP00000304440 | ENSP00000223026 | hyaluronan synthase 3; Plays a role in hyaluronan/hyaluronic acid (HA) synthesis | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide | 0.549 |
HYAL4 | ADAM2 | ENSP00000223026 | ENSP00000265708 | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | 0.474 |
HYAL4 | ARSB | ENSP00000223026 | ENSP00000264914 | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide | arylsulfatase B | 0.901 |
HYAL4 | CD44 | ENSP00000223026 | ENSP00000398632 | hyaluronoglucosaminidase 4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide | CD44 molecule (Indian blood group) | 0.488 |