| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYBRD1 | HAMP | ENSP00000319141 | ENSP00000222304 | cytochrome b reductase 1 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | 0.809 |
| CYBRD1 | HEPH | ENSP00000319141 | ENSP00000430620 | cytochrome b reductase 1 | hephaestin; May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1 | 0.824 |
| CYBRD1 | HFE | ENSP00000319141 | ENSP00000417404 | cytochrome b reductase 1 | hemochromatosis | 0.662 |
| CYBRD1 | SLC11A2 | ENSP00000319141 | ENSP00000378364 | cytochrome b reductase 1 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 0.987 |
| CYBRD1 | SLC40A1 | ENSP00000319141 | ENSP00000261024 | cytochrome b reductase 1 | solute carrier family 40 (iron-regulated transporter), member 1; May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin) | 0.838 |
| CYBRD1 | TF | ENSP00000319141 | ENSP00000385834 | cytochrome b reductase 1 | transferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation | 0.582 |
| CYBRD1 | TFR2 | ENSP00000319141 | ENSP00000223051 | cytochrome b reductase 1 | transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation | 0.725 |
| CYBRD1 | TMPRSS6 | ENSP00000319141 | ENSP00000334962 | cytochrome b reductase 1 | transmembrane protease, serine 6 | 0.540 |
| EPOR | TF | ENSP00000222139 | ENSP00000385834 | erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase | transferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation | 0.479 |
| EPOR | TFR2 | ENSP00000222139 | ENSP00000223051 | erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase | transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation | 0.846 |
| EPOR | UBC | ENSP00000222139 | ENSP00000344818 | erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase | ubiquitin C | 0.917 |
| HAMP | CYBRD1 | ENSP00000222304 | ENSP00000319141 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | cytochrome b reductase 1 | 0.809 |
| HAMP | HEPH | ENSP00000222304 | ENSP00000430620 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | hephaestin; May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1 | 0.483 |
| HAMP | HFE | ENSP00000222304 | ENSP00000417404 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | hemochromatosis | 0.953 |
| HAMP | SLC11A2 | ENSP00000222304 | ENSP00000378364 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 | 0.918 |
| HAMP | SLC40A1 | ENSP00000222304 | ENSP00000261024 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | solute carrier family 40 (iron-regulated transporter), member 1; May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin) | 0.973 |
| HAMP | TF | ENSP00000222304 | ENSP00000385834 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | transferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation | 0.606 |
| HAMP | TFR2 | ENSP00000222304 | ENSP00000223051 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation | 0.836 |
| HAMP | TMPRSS6 | ENSP00000222304 | ENSP00000334962 | hepcidin antimicrobial peptide; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages (By similarity) | transmembrane protease, serine 6 | 0.680 |
| HEPH | CYBRD1 | ENSP00000430620 | ENSP00000319141 | hephaestin; May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1 | cytochrome b reductase 1 | 0.824 |
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