node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADAMTS14 | BMP1 | ENSP00000362304 | ENSP00000305714 | ADAM metallopeptidase with thrombospondin type 1 motif, 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity | bone morphogenetic protein 1 | 0.944 |
ADAMTS14 | PCOLCE | ENSP00000362304 | ENSP00000223061 | ADAM metallopeptidase with thrombospondin type 1 motif, 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | 0.921 |
ADAMTS2 | BMP1 | ENSP00000251582 | ENSP00000305714 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | bone morphogenetic protein 1 | 0.941 |
ADAMTS2 | PCOLCE | ENSP00000251582 | ENSP00000223061 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | 0.919 |
ADAMTS3 | BMP1 | ENSP00000286657 | ENSP00000305714 | ADAM metallopeptidase with thrombospondin type 1 motif, 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens | bone morphogenetic protein 1 | 0.923 |
ADAMTS3 | PCOLCE | ENSP00000286657 | ENSP00000223061 | ADAM metallopeptidase with thrombospondin type 1 motif, 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | 0.917 |
B2M | PCOLCE | ENSP00000452780 | ENSP00000223061 | beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | 0.914 |
BMP1 | ADAMTS14 | ENSP00000305714 | ENSP00000362304 | bone morphogenetic protein 1 | ADAM metallopeptidase with thrombospondin type 1 motif, 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity | 0.944 |
BMP1 | ADAMTS2 | ENSP00000305714 | ENSP00000251582 | bone morphogenetic protein 1 | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | 0.941 |
BMP1 | ADAMTS3 | ENSP00000305714 | ENSP00000286657 | bone morphogenetic protein 1 | ADAM metallopeptidase with thrombospondin type 1 motif, 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens | 0.923 |
BMP1 | NTSR1 | ENSP00000305714 | ENSP00000359532 | bone morphogenetic protein 1 | neurotensin receptor 1 (high affinity); Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.842 |
BMP1 | PCOLCE | ENSP00000305714 | ENSP00000223061 | bone morphogenetic protein 1 | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | 0.922 |
COL3A1 | PCOLCE | ENSP00000304408 | ENSP00000223061 | collagen, type III, alpha 1 | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | 0.737 |
COL3A1 | THBS1 | ENSP00000304408 | ENSP00000260356 | collagen, type III, alpha 1 | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.884 |
NCK1 | PCOLCE | ENSP00000288986 | ENSP00000223061 | NCK adaptor protein 1; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | 0.661 |
NTSR1 | BMP1 | ENSP00000359532 | ENSP00000305714 | neurotensin receptor 1 (high affinity); Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system | bone morphogenetic protein 1 | 0.842 |
NTSR1 | PCOLCE | ENSP00000359532 | ENSP00000223061 | neurotensin receptor 1 (high affinity); Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | 0.640 |
PCOLCE | ADAMTS14 | ENSP00000223061 | ENSP00000362304 | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | ADAM metallopeptidase with thrombospondin type 1 motif, 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity | 0.921 |
PCOLCE | ADAMTS2 | ENSP00000223061 | ENSP00000251582 | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis | 0.919 |
PCOLCE | ADAMTS3 | ENSP00000223061 | ENSP00000286657 | procollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity | ADAM metallopeptidase with thrombospondin type 1 motif, 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens | 0.917 |