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B2M B2M PLG PLG ADAMTS14 ADAMTS14 THBS1 THBS1 ADAMTS2 ADAMTS2 PCOLCE PCOLCE BMP1 BMP1 COL3A1 COL3A1 NTSR1 NTSR1 ADAMTS3 ADAMTS3 NCK1 NCK1
"PCOLCE" - procollagen C-endopeptidase enhancer in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
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protein homology
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PCOLCEprocollagen C-endopeptidase enhancer; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity (449 aa)    
Predicted Functional Partners:
BMP1
bone morphogenetic protein 1 (986 aa)
          score_image score_image score_image 0.922
ADAMTS14
ADAM metallopeptidase with thrombospondin type 1 motif, 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (1226 aa)
          score_image score_image   0.921
ADAMTS2
ADAM metallopeptidase with thrombospondin type 1 motif, 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis (1211 aa)
      score_image   score_image score_image   0.919
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens (1205 aa)
      score_image   score_image score_image   0.917
B2M
beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity) (119 aa)
        score_image   score_image   0.914
PLG
plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa)
        score_image   score_image   0.828
COL3A1
collagen, type III, alpha 1 (1466 aa)
      score_image score_image   score_image   0.737
NCK1
NCK adaptor protein 1; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA (377 aa)
            score_image   0.661
THBS1
thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties (1170 aa)
        score_image   score_image   0.646
NTSR1
neurotensin receptor 1 (high affinity); Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system (418 aa)
            score_image   0.640
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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