node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALB | PLG | ENSP00000295897 | ENSP00000308938 | albumin | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.977 |
ALB | SERPINE1 | ENSP00000295897 | ENSP00000223095 | albumin | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Serine protease inhibitor. This inhibitor acts as ’bait’ for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis | 0.993 |
ALB | SMAD3 | ENSP00000295897 | ENSP00000332973 | albumin | SMAD family member 3 | 0.480 |
ALB | SMAD4 | ENSP00000295897 | ENSP00000341551 | albumin | SMAD family member 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for syngernistic transcriptional activity in response to TGF-beta. [...] | 0.506 |
ALB | TGFB1 | ENSP00000295897 | ENSP00000221930 | albumin | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.963 |
ALB | TP53 | ENSP00000295897 | ENSP00000269305 | albumin | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.960 |
ALB | VTN | ENSP00000295897 | ENSP00000226218 | albumin | vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway | 0.751 |
PLAT | PLAU | ENSP00000220809 | ENSP00000361850 | plasminogen activator, tissue | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | 0.620 |
PLAT | PLG | ENSP00000220809 | ENSP00000308938 | plasminogen activator, tissue | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.963 |
PLAT | SERPINE1 | ENSP00000220809 | ENSP00000223095 | plasminogen activator, tissue | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Serine protease inhibitor. This inhibitor acts as ’bait’ for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis | 0.999 |
PLAT | TP53 | ENSP00000220809 | ENSP00000269305 | plasminogen activator, tissue | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.834 |
PLAU | PLAT | ENSP00000361850 | ENSP00000220809 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | plasminogen activator, tissue | 0.620 |
PLAU | PLAUR | ENSP00000361850 | ENSP00000339328 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | plasminogen activator, urokinase receptor | 0.999 |
PLAU | PLG | ENSP00000361850 | ENSP00000308938 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.962 |
PLAU | SERPINE1 | ENSP00000361850 | ENSP00000223095 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Serine protease inhibitor. This inhibitor acts as ’bait’ for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis | 0.999 |
PLAU | TP53 | ENSP00000361850 | ENSP00000269305 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.847 |
PLAU | VTN | ENSP00000361850 | ENSP00000226218 | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway | 0.932 |
PLAUR | PLAU | ENSP00000339328 | ENSP00000361850 | plasminogen activator, urokinase receptor | plasminogen activator, urokinase; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin | 0.999 |
PLAUR | PLG | ENSP00000339328 | ENSP00000308938 | plasminogen activator, urokinase receptor | plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.961 |
PLAUR | SERPINE1 | ENSP00000339328 | ENSP00000223095 | plasminogen activator, urokinase receptor | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Serine protease inhibitor. This inhibitor acts as ’bait’ for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis | 0.991 |