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FSD1L FSD1L TMEM38B TMEM38B FKTN FKTN DAG1 DAG1 LAMA2 LAMA2 DMD DMD TCAP TCAP POMT1 POMT1 FKRP FKRP POMGNT1 POMGNT1 POMT2 POMT2
"FKTN" - fukutin in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
FKTNfukutin; May be a glycosyltransferase which participates in glycosylation of alpha-dystroglycan/DAG1. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (461 aa)    
Predicted Functional Partners:
POMGNT1
protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase; Participates in O-mannosyl glycosylation. May be responsible for the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O- Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins. Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity (660 aa)
            score_image   0.973
POMT1
protein-O-mannosyltransferase 1 (747 aa)
            score_image   0.878
FKRP
fukutin related protein; Could be a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG1) (495 aa)
            score_image   0.872
POMT2
protein-O-mannosyltransferase 2; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient (750 aa)
            score_image   0.827
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1); The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization (895 aa)
            score_image   0.818
TCAP
titin-cap; Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (167 aa)
            score_image   0.659
FSD1L
fibronectin type III and SPRY domain containing 1-like (530 aa)
            score_image   0.657
DMD
dystrophin (3685 aa)
            score_image   0.642
LAMA2
laminin, alpha 2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components (3122 aa)
            score_image   0.638
TMEM38B
transmembrane protein 38B; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity) (291 aa)
            score_image   0.622
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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