TNFSF8 protein (Homo sapiens) - STRING network view

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TNFSF8

tumor necrosis factor (ligand) superfamily, member 8; Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells (234 aa)

Predicted Functional Partners:

TNFRSF8

0.998

CD70

0.707

TNFSF9

0.700

TNFSF4

0.634

ANG

0.576

CD40LG

0.525

TNFRSF4

0.520

TNFSF15

0.517

CD27

0.516

TNFSF18

0.503

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANG	TNFSF8	ENSP00000336762	ENSP00000223795	angiogenin, ribonuclease, RNase A family, 5; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo	tumor necrosis factor (ligand) superfamily, member 8; Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells	0.576
CD27	CD40LG	ENSP00000266557	ENSP00000359663	CD27 molecule; Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1	CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching	0.955
CD27	CD70	ENSP00000266557	ENSP00000245903	CD27 molecule; Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1	CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells	0.994
CD27	TNFRSF4	ENSP00000266557	ENSP00000368538	CD27 molecule; Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1	tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34	0.684
CD27	TNFRSF8	ENSP00000266557	ENSP00000263932	CD27 molecule; Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1	tumor necrosis factor receptor superfamily, member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B	0.561
CD27	TNFSF4	ENSP00000266557	ENSP00000281834	CD27 molecule; Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1	tumor necrosis factor (ligand) superfamily, member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production	0.412
CD27	TNFSF8	ENSP00000266557	ENSP00000223795	CD27 molecule; Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1	tumor necrosis factor (ligand) superfamily, member 8; Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells	0.516
CD27	TNFSF9	ENSP00000266557	ENSP00000245817	CD27 molecule; Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1	tumor necrosis factor (ligand) superfamily, member 9; Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages	0.508
CD40LG	CD27	ENSP00000359663	ENSP00000266557	CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching	CD27 molecule; Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1	0.955
CD40LG	CD70	ENSP00000359663	ENSP00000245903	CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching	CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells	0.623
CD40LG	TNFRSF4	ENSP00000359663	ENSP00000368538	CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching	tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34	0.598
CD40LG	TNFRSF8	ENSP00000359663	ENSP00000263932	CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching	tumor necrosis factor receptor superfamily, member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B	0.568
CD40LG	TNFSF18	ENSP00000359663	ENSP00000385470	CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching	tumor necrosis factor (ligand) superfamily, member 18; Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B	0.643
CD40LG	TNFSF4	ENSP00000359663	ENSP00000281834	CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching	tumor necrosis factor (ligand) superfamily, member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production	0.450
CD40LG	TNFSF8	ENSP00000359663	ENSP00000223795	CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching	tumor necrosis factor (ligand) superfamily, member 8; Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells	0.525
CD40LG	TNFSF9	ENSP00000359663	ENSP00000245817	CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching	tumor necrosis factor (ligand) superfamily, member 9; Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages	0.499
CD70	CD27	ENSP00000245903	ENSP00000266557	CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells	CD27 molecule; Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1	0.994
CD70	CD40LG	ENSP00000245903	ENSP00000359663	CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells	CD40 ligand; Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching	0.623
CD70	TNFRSF4	ENSP00000245903	ENSP00000368538	CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells	tumor necrosis factor receptor superfamily, member 4; Receptor for TNFSF4/OX40L/GP34	0.581
CD70	TNFRSF8	ENSP00000245903	ENSP00000263932	CD70 molecule; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells	tumor necrosis factor receptor superfamily, member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B	0.507

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