node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL4A6 | CRYBA4 | ENSP00000361290 | ENSP00000346805 | collagen, type IV, alpha 6 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | 0.900 |
COL4A6 | DEDD2 | ENSP00000361290 | ENSP00000470082 | collagen, type IV, alpha 6 | death effector domain containing 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 | 0.900 |
COL4A6 | HSBP1 | ENSP00000361290 | ENSP00000392896 | collagen, type IV, alpha 6 | heat shock factor binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process | 0.900 |
COL4A6 | HSP90AA1 | ENSP00000361290 | ENSP00000335153 | collagen, type IV, alpha 6 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.903 |
COL4A6 | MRPL18 | ENSP00000361290 | ENSP00000356001 | collagen, type IV, alpha 6 | mitochondrial ribosomal protein L18; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA | 0.900 |
COL4A6 | RLN1 | ENSP00000361290 | ENSP00000223862 | collagen, type IV, alpha 6 | relaxin 1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix | 0.900 |
COL4A6 | RPA2 | ENSP00000361290 | ENSP00000363021 | collagen, type IV, alpha 6 | replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage | 0.900 |
COL4A6 | RPS19BP1 | ENSP00000361290 | ENSP00000333948 | collagen, type IV, alpha 6 | ribosomal protein S19 binding protein 1; Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity | 0.900 |
COL4A6 | SERPINH1 | ENSP00000361290 | ENSP00000350894 | collagen, type IV, alpha 6 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen | 0.903 |
CRYBA4 | COL4A6 | ENSP00000346805 | ENSP00000361290 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | collagen, type IV, alpha 6 | 0.900 |
CRYBA4 | DEDD2 | ENSP00000346805 | ENSP00000470082 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | death effector domain containing 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 | 0.900 |
CRYBA4 | HSBP1 | ENSP00000346805 | ENSP00000392896 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | heat shock factor binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process | 0.900 |
CRYBA4 | HSP90AA1 | ENSP00000346805 | ENSP00000335153 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.900 |
CRYBA4 | MRPL18 | ENSP00000346805 | ENSP00000356001 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | mitochondrial ribosomal protein L18; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA | 0.900 |
CRYBA4 | RLN1 | ENSP00000346805 | ENSP00000223862 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | relaxin 1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix | 0.900 |
CRYBA4 | RPA2 | ENSP00000346805 | ENSP00000363021 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | replication protein A2, 32kDa; Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage | 0.900 |
CRYBA4 | RPS19BP1 | ENSP00000346805 | ENSP00000333948 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | ribosomal protein S19 binding protein 1; Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity | 0.900 |
CRYBA4 | SERPINH1 | ENSP00000346805 | ENSP00000350894 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen | 0.900 |
DEDD2 | COL4A6 | ENSP00000470082 | ENSP00000361290 | death effector domain containing 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 | collagen, type IV, alpha 6 | 0.900 |
DEDD2 | CRYBA4 | ENSP00000470082 | ENSP00000346805 | death effector domain containing 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 | crystallin, beta A4; Crystallins are the dominant structural components of the vertebrate eye lens | 0.900 |