SFXN3 protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

SFXN3

sideroflexin 3; Potential iron transporter (325 aa)

Predicted Functional Partners:

TIMM50

0.906

MYC

0.900

MAX

0.900

TOMM20

0.898

FAM3C

0.862

TIMM17A

0.662

SFXN1

0.646

SPTAN1

0.644

VDAC2

0.644

VAMP2

0.644

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM3C	SFXN3	ENSP00000353025	ENSP00000224807	family with sequence similarity 3, member C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition	sideroflexin 3; Potential iron transporter	0.862
MAX	MYC	ENSP00000351490	ENSP00000367207	MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity	v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes	0.999
MAX	SFXN3	ENSP00000351490	ENSP00000224807	MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity	sideroflexin 3; Potential iron transporter	0.900
MYC	MAX	ENSP00000367207	ENSP00000351490	v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes	MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity	0.999
MYC	SFXN3	ENSP00000367207	ENSP00000224807	v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes	sideroflexin 3; Potential iron transporter	0.900
SFXN1	SFXN3	ENSP00000316905	ENSP00000224807	sideroflexin 1; Might be involved in the transport of a component required for iron utilization into or out of the mitochondria	sideroflexin 3; Potential iron transporter	0.646
SFXN1	TIMM50	ENSP00000316905	ENSP00000318115	sideroflexin 1; Might be involved in the transport of a component required for iron utilization into or out of the mitochondria	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body	0.896
SFXN1	TOMM20	ENSP00000316905	ENSP00000355566	sideroflexin 1; Might be involved in the transport of a component required for iron utilization into or out of the mitochondria	translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity)	0.910
SFXN3	FAM3C	ENSP00000224807	ENSP00000353025	sideroflexin 3; Potential iron transporter	family with sequence similarity 3, member C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition	0.862
SFXN3	MAX	ENSP00000224807	ENSP00000351490	sideroflexin 3; Potential iron transporter	MYC associated factor X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5’-CAC[GA]TG-3’. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 ’Lys-9’ histone methyltransferase activity	0.900
SFXN3	MYC	ENSP00000224807	ENSP00000367207	sideroflexin 3; Potential iron transporter	v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes	0.900
SFXN3	SFXN1	ENSP00000224807	ENSP00000316905	sideroflexin 3; Potential iron transporter	sideroflexin 1; Might be involved in the transport of a component required for iron utilization into or out of the mitochondria	0.646
SFXN3	SPTAN1	ENSP00000224807	ENSP00000361824	sideroflexin 3; Potential iron transporter	spectrin, alpha, non-erythrocytic 1	0.644
SFXN3	TIMM17A	ENSP00000224807	ENSP00000356256	sideroflexin 3; Potential iron transporter	translocase of inner mitochondrial membrane 17 homolog A (yeast); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane	0.662
SFXN3	TIMM50	ENSP00000224807	ENSP00000318115	sideroflexin 3; Potential iron transporter	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo. Isoform 2 may participate in the release of snRNPs and SMN from the Cajal body	0.906
SFXN3	TOMM20	ENSP00000224807	ENSP00000355566	sideroflexin 3; Potential iron transporter	translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity)	0.898
SFXN3	VAMP2	ENSP00000224807	ENSP00000314214	sideroflexin 3; Potential iron transporter	vesicle-associated membrane protein 2 (synaptobrevin 2); Involved in the targeting and/or fusion of transport vesicles to their target membrane	0.644
SFXN3	VDAC2	ENSP00000224807	ENSP00000361635	sideroflexin 3; Potential iron transporter	voltage-dependent anion channel 2; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective	0.644
SPTAN1	SFXN3	ENSP00000361824	ENSP00000224807	spectrin, alpha, non-erythrocytic 1	sideroflexin 3; Potential iron transporter	0.644
TIMM17A	SFXN3	ENSP00000356256	ENSP00000224807	translocase of inner mitochondrial membrane 17 homolog A (yeast); Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane	sideroflexin 3; Potential iron transporter	0.662

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