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STRINGSTRING
HSPA5 HSPA5 HSPA14 HSPA14 HYOU1 HYOU1 HSPA8 HSPA8 DNAJB1 DNAJB1 DNAJC12 DNAJC12 HSPA4 HSPA4 HSPA4L HSPA4L HSPA12A HSPA12A HSPA1A HSPA1A HSPA12B HSPA12B
"DNAJC12" - DnaJ in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DNAJC12DnaJ (Hsp40) homolog, subfamily C, member 12 (198 aa)    
Predicted Functional Partners:
HSPA4
heat shock 70kDa protein 4 (840 aa)
 score_image     score_image score_image   score_image   0.840
HSPA12A
heat shock 70kDa protein 12A (675 aa)
 score_image     score_image score_image   score_image   0.804
HSPA8
heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (646 aa)
 score_image     score_image score_image   score_image   0.777
HSPA14
heat shock 70kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (509 aa)
 score_image     score_image score_image   score_image   0.774
HSPA12B
heat shock 70kD protein 12B (686 aa)
 score_image     score_image score_image   score_image   0.765
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP (340 aa)
         score_image   score_image   0.762
HSPA5
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER (654 aa)
 score_image     score_image score_image   score_image   0.761
HSPA1A
heat shock 70kDa protein 1A (641 aa)
 score_image     score_image score_image   score_image   0.757
HYOU1
hypoxia up-regulated 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding (999 aa)
 score_image     score_image score_image   score_image   0.756
HSPA4L
heat shock 70kDa protein 4-like; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity) (839 aa)
 score_image     score_image score_image   score_image   0.746
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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