node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABAT | P2RX5 | ENSP00000268251 | ENSP00000225328 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | purinergic receptor P2X, ligand-gated ion channel, 5 | 0.477 |
ABAT | PTPRA | ENSP00000268251 | ENSP00000369756 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | protein tyrosine phosphatase, receptor type, A | 0.582 |
ABAT | PTPRE | ENSP00000268251 | ENSP00000254667 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | protein tyrosine phosphatase, receptor type, E; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity) | 0.584 |
CD80 | P2RX5 | ENSP00000264246 | ENSP00000225328 | CD80 molecule; Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor | purinergic receptor P2X, ligand-gated ion channel, 5 | 0.515 |
CENPM | HMSD | ENSP00000215980 | ENSP00000386207 | centromere protein M; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres | histocompatibility (minor) serpin domain containing; Putative serine protease inhibitor (By similarity) | 0.568 |
CENPM | P2RX5 | ENSP00000215980 | ENSP00000225328 | centromere protein M; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres | purinergic receptor P2X, ligand-gated ion channel, 5 | 0.505 |
HMSD | CENPM | ENSP00000386207 | ENSP00000215980 | histocompatibility (minor) serpin domain containing; Putative serine protease inhibitor (By similarity) | centromere protein M; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres | 0.568 |
HMSD | P2RX5 | ENSP00000386207 | ENSP00000225328 | histocompatibility (minor) serpin domain containing; Putative serine protease inhibitor (By similarity) | purinergic receptor P2X, ligand-gated ion channel, 5 | 0.565 |
P2RX5 | ABAT | ENSP00000225328 | ENSP00000268251 | purinergic receptor P2X, ligand-gated ion channel, 5 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | 0.477 |
P2RX5 | CD80 | ENSP00000225328 | ENSP00000264246 | purinergic receptor P2X, ligand-gated ion channel, 5 | CD80 molecule; Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor | 0.515 |
P2RX5 | CENPM | ENSP00000225328 | ENSP00000215980 | purinergic receptor P2X, ligand-gated ion channel, 5 | centromere protein M; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres | 0.505 |
P2RX5 | HMSD | ENSP00000225328 | ENSP00000386207 | purinergic receptor P2X, ligand-gated ion channel, 5 | histocompatibility (minor) serpin domain containing; Putative serine protease inhibitor (By similarity) | 0.565 |
P2RX5 | P2RY1 | ENSP00000225328 | ENSP00000304767 | purinergic receptor P2X, ligand-gated ion channel, 5 | purinergic receptor P2Y, G-protein coupled, 1; Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation | 0.540 |
P2RX5 | P2RY2 | ENSP00000225328 | ENSP00000310305 | purinergic receptor P2X, ligand-gated ion channel, 5 | purinergic receptor P2Y, G-protein coupled, 2; Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP | 0.569 |
P2RX5 | P2RY4 | ENSP00000225328 | ENSP00000363643 | purinergic receptor P2X, ligand-gated ion channel, 5 | pyrimidinergic receptor P2Y, G-protein coupled, 4; Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP | 0.499 |
P2RX5 | P2RY6 | ENSP00000225328 | ENSP00000309771 | purinergic receptor P2X, ligand-gated ion channel, 5 | pyrimidinergic receptor P2Y, G-protein coupled, 6; Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system | 0.583 |
P2RX5 | PTPRA | ENSP00000225328 | ENSP00000369756 | purinergic receptor P2X, ligand-gated ion channel, 5 | protein tyrosine phosphatase, receptor type, A | 0.456 |
P2RX5 | PTPRE | ENSP00000225328 | ENSP00000254667 | purinergic receptor P2X, ligand-gated ion channel, 5 | protein tyrosine phosphatase, receptor type, E; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity) | 0.456 |
P2RY1 | P2RX5 | ENSP00000304767 | ENSP00000225328 | purinergic receptor P2Y, G-protein coupled, 1; Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation | purinergic receptor P2X, ligand-gated ion channel, 5 | 0.540 |
P2RY1 | P2RY2 | ENSP00000304767 | ENSP00000310305 | purinergic receptor P2Y, G-protein coupled, 1; Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation | purinergic receptor P2Y, G-protein coupled, 2; Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP | 0.913 |