node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1QL4 | CCDC47 | ENSP00000335285 | ENSP00000225726 | complement component 1, q subcomponent-like 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity) | coiled-coil domain containing 47 | 0.700 |
CCDC47 | C1QL4 | ENSP00000225726 | ENSP00000335285 | coiled-coil domain containing 47 | complement component 1, q subcomponent-like 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity) | 0.700 |
CCDC47 | CCDC53 | ENSP00000225726 | ENSP00000240079 | coiled-coil domain containing 47 | coiled-coil domain containing 53; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting | 0.575 |
CCDC47 | CCDC93 | ENSP00000225726 | ENSP00000365477 | coiled-coil domain containing 47 | coiled-coil domain containing 93 | 0.587 |
CCDC47 | EIF3D | ENSP00000225726 | ENSP00000216190 | coiled-coil domain containing 47 | eukaryotic translation initiation factor 3, subunit D; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | 0.565 |
CCDC47 | IRAK2 | ENSP00000225726 | ENSP00000256458 | coiled-coil domain containing 47 | interleukin-1 receptor-associated kinase 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization | 0.730 |
CCDC47 | IRF7 | ENSP00000225726 | ENSP00000329411 | coiled-coil domain containing 47 | interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] | 0.582 |
CCDC47 | TIRAP | ENSP00000225726 | ENSP00000376445 | coiled-coil domain containing 47 | toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6 | 0.582 |
CCDC47 | TMEM173 | ENSP00000225726 | ENSP00000331288 | coiled-coil domain containing 47 | transmembrane protein 173; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol- upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated [...] | 0.582 |
CCDC47 | UBC | ENSP00000225726 | ENSP00000344818 | coiled-coil domain containing 47 | ubiquitin C | 0.879 |
CCDC47 | UNC93B1 | ENSP00000225726 | ENSP00000227471 | coiled-coil domain containing 47 | unc-93 homolog B1 (C. elegans); Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B- cells removal | 0.582 |
CCDC53 | CCDC47 | ENSP00000240079 | ENSP00000225726 | coiled-coil domain containing 53; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting | coiled-coil domain containing 47 | 0.575 |
CCDC53 | CCDC93 | ENSP00000240079 | ENSP00000365477 | coiled-coil domain containing 53; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting | coiled-coil domain containing 93 | 0.517 |
CCDC53 | EIF3D | ENSP00000240079 | ENSP00000216190 | coiled-coil domain containing 53; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting | eukaryotic translation initiation factor 3, subunit D; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | 0.533 |
CCDC93 | CCDC47 | ENSP00000365477 | ENSP00000225726 | coiled-coil domain containing 93 | coiled-coil domain containing 47 | 0.587 |
CCDC93 | CCDC53 | ENSP00000365477 | ENSP00000240079 | coiled-coil domain containing 93 | coiled-coil domain containing 53; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting | 0.517 |
CCDC93 | EIF3D | ENSP00000365477 | ENSP00000216190 | coiled-coil domain containing 93 | eukaryotic translation initiation factor 3, subunit D; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | 0.430 |
CCDC93 | UBC | ENSP00000365477 | ENSP00000344818 | coiled-coil domain containing 93 | ubiquitin C | 0.620 |
EIF3D | CCDC47 | ENSP00000216190 | ENSP00000225726 | eukaryotic translation initiation factor 3, subunit D; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | coiled-coil domain containing 47 | 0.565 |
EIF3D | CCDC53 | ENSP00000216190 | ENSP00000240079 | eukaryotic translation initiation factor 3, subunit D; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2-GTP-methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination riboso [...] | coiled-coil domain containing 53; Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting | 0.533 |