node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABAT | ALDH3A1 | ENSP00000268251 | ENSP00000225740 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | 0.943 |
ACSS1 | ACSS2 | ENSP00000316924 | ENSP00000253382 | acyl-CoA synthetase short-chain family member 1 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | 0.907 |
ACSS1 | ADH1A | ENSP00000316924 | ENSP00000209668 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.549 |
ACSS1 | ADH1B | ENSP00000316924 | ENSP00000306606 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.486 |
ACSS1 | ADH4 | ENSP00000316924 | ENSP00000265512 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 4 (class II), pi polypeptide | 0.538 |
ACSS1 | ADH6 | ENSP00000316924 | ENSP00000378359 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 6 (class V) | 0.549 |
ACSS1 | ADH7 | ENSP00000316924 | ENSP00000420269 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | 0.549 |
ACSS1 | ALDH3A1 | ENSP00000316924 | ENSP00000225740 | acyl-CoA synthetase short-chain family member 1 | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | 0.960 |
ACSS2 | ACSS1 | ENSP00000253382 | ENSP00000316924 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | acyl-CoA synthetase short-chain family member 1 | 0.907 |
ACSS2 | ADH1A | ENSP00000253382 | ENSP00000209668 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.428 |
ACSS2 | ADH4 | ENSP00000253382 | ENSP00000265512 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | alcohol dehydrogenase 4 (class II), pi polypeptide | 0.423 |
ACSS2 | ADH6 | ENSP00000253382 | ENSP00000378359 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | alcohol dehydrogenase 6 (class V) | 0.428 |
ACSS2 | ADH7 | ENSP00000253382 | ENSP00000420269 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | 0.428 |
ACSS2 | ALDH3A1 | ENSP00000253382 | ENSP00000225740 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | 0.952 |
ADH1A | ACSS1 | ENSP00000209668 | ENSP00000316924 | alcohol dehydrogenase 1A (class I), alpha polypeptide | acyl-CoA synthetase short-chain family member 1 | 0.549 |
ADH1A | ACSS2 | ENSP00000209668 | ENSP00000253382 | alcohol dehydrogenase 1A (class I), alpha polypeptide | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | 0.428 |
ADH1A | ALDH3A1 | ENSP00000209668 | ENSP00000225740 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | 0.957 |
ADH1A | GSTA1 | ENSP00000209668 | ENSP00000335620 | alcohol dehydrogenase 1A (class I), alpha polypeptide | glutathione S-transferase alpha 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles | 0.908 |
ADH1B | ACSS1 | ENSP00000306606 | ENSP00000316924 | alcohol dehydrogenase 1B (class I), beta polypeptide | acyl-CoA synthetase short-chain family member 1 | 0.486 |
ADH1B | ALDH3A1 | ENSP00000306606 | ENSP00000225740 | alcohol dehydrogenase 1B (class I), beta polypeptide | aldehyde dehydrogenase 3 family, member A1; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes | 0.960 |