node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABI3 | ABI3BP | ENSP00000225941 | ENSP00000284322 | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | ABI family, member 3 (NESH) binding protein | 0.957 |
ABI3 | ADAMTSL1 | ENSP00000225941 | ENSP00000369921 | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | ADAMTS-like 1 | 0.835 |
ABI3 | BAIAP2 | ENSP00000225941 | ENSP00000316338 | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | BAI1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promotin [...] | 0.841 |
ABI3 | FBLN2 | ENSP00000225941 | ENSP00000384169 | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent | 0.812 |
ABI3 | NCKAP1 | ENSP00000225941 | ENSP00000354251 | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | NCK-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 | 0.842 |
ABI3 | RAC1 | ENSP00000225941 | ENSP00000348461 | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.847 |
ABI3 | RAC2 | ENSP00000225941 | ENSP00000249071 | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase | 0.847 |
ABI3 | RAC3 | ENSP00000225941 | ENSP00000304283 | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles | 0.847 |
ABI3 | SOS1 | ENSP00000225941 | ENSP00000384675 | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity) | 0.892 |
ABI3 | WASF2 | ENSP00000225941 | ENSP00000396211 | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | WAS protein family, member 2; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex | 0.886 |
ABI3BP | ABI3 | ENSP00000284322 | ENSP00000225941 | ABI family, member 3 (NESH) binding protein | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | 0.957 |
ADAMTSL1 | ABI3 | ENSP00000369921 | ENSP00000225941 | ADAMTS-like 1 | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | 0.835 |
BAIAP2 | ABI3 | ENSP00000316338 | ENSP00000225941 | BAI1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promotin [...] | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | 0.841 |
BAIAP2 | NCKAP1 | ENSP00000316338 | ENSP00000354251 | BAI1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promotin [...] | NCK-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 | 0.948 |
BAIAP2 | RAC1 | ENSP00000316338 | ENSP00000348461 | BAI1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promotin [...] | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.999 |
BAIAP2 | RAC2 | ENSP00000316338 | ENSP00000249071 | BAI1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promotin [...] | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase | 0.842 |
BAIAP2 | RAC3 | ENSP00000316338 | ENSP00000304283 | BAI1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promotin [...] | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles | 0.903 |
BAIAP2 | WASF2 | ENSP00000316338 | ENSP00000396211 | BAI1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promotin [...] | WAS protein family, member 2; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex | 0.998 |
FBLN2 | ABI3 | ENSP00000384169 | ENSP00000225941 | fibulin 2; Its binding to fibronectin and some other ligands is calcium dependent | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | 0.812 |
NCKAP1 | ABI3 | ENSP00000354251 | ENSP00000225941 | NCK-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1 | ABI family, member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility | 0.842 |