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RPGR RPGR HERC1 HERC1 HECTD4 HECTD4 RANBP1 RANBP1 NUTF2 NUTF2 RCCD1 RCCD1 RAN RAN RANGRF RANGRF RCC1 RCC1 SCN5A SCN5A WBSCR16 WBSCR16
"RANGRF" - RAN guanine nucleotide release factor in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
RANGRFRAN guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A (186 aa)    
Predicted Functional Partners:
RAN
RAN, member RAS oncogene family (216 aa)
        score_image   score_image   0.995
RANBP1
RAN binding protein 1; Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane (201 aa)
        score_image   score_image   0.942
SCN5A
sodium channel, voltage-gated, type V, alpha subunit (2016 aa)
            score_image   0.895
RCC1
regulator of chromosome condensation 1; Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly (452 aa)
        score_image   score_image   0.848
NUTF2
nuclear transport factor 2; Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import (127 aa)
        score_image   score_image   0.722
WBSCR16
Williams-Beuren syndrome chromosome region 16 (464 aa)
        score_image   score_image   0.681
HECTD4
HECT domain containing E3 ubiquitin protein ligase 4 (4272 aa)
        score_image   score_image   0.680
HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (4861 aa)
        score_image   score_image   0.680
RCCD1
RCC1 domain containing 1 (376 aa)
        score_image   score_image   0.680
RPGR
retinitis pigmentosa GTPase regulator (1152 aa)
        score_image   score_image   0.680
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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