node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALDOA | ALDOC | ENSP00000336927 | ENSP00000226253 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | aldolase C, fructose-bisphosphate | 0.981 |
ALDOA | ENO3 | ENSP00000336927 | ENSP00000324105 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | 0.985 |
ALDOA | FBP2 | ENSP00000336927 | ENSP00000364486 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | fructose-1,6-bisphosphatase 2 | 0.960 |
ALDOA | GAPDH | ENSP00000336927 | ENSP00000229239 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.984 |
ALDOA | GAPDHS | ENSP00000336927 | ENSP00000222286 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) | 0.974 |
ALDOA | GPI | ENSP00000336927 | ENSP00000405573 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | 0.980 |
ALDOA | PFKL | ENSP00000336927 | ENSP00000269848 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.988 |
ALDOA | PFKM | ENSP00000336927 | ENSP00000345771 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.986 |
ALDOA | PFKP | ENSP00000336927 | ENSP00000370517 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.988 |
ALDOA | PKM | ENSP00000336927 | ENSP00000320171 | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | pyruvate kinase, muscle | 0.987 |
ALDOC | ALDOA | ENSP00000226253 | ENSP00000336927 | aldolase C, fructose-bisphosphate | aldolase A, fructose-bisphosphate; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity) | 0.981 |
ALDOC | ENO3 | ENSP00000226253 | ENSP00000324105 | aldolase C, fructose-bisphosphate | enolase 3 (beta, muscle); Appears to have a function in striated muscle development and regeneration | 0.981 |
ALDOC | FBP2 | ENSP00000226253 | ENSP00000364486 | aldolase C, fructose-bisphosphate | fructose-1,6-bisphosphatase 2 | 0.966 |
ALDOC | GAPDH | ENSP00000226253 | ENSP00000229239 | aldolase C, fructose-bisphosphate | glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...] | 0.982 |
ALDOC | GAPDHS | ENSP00000226253 | ENSP00000222286 | aldolase C, fructose-bisphosphate | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity) | 0.974 |
ALDOC | GPI | ENSP00000226253 | ENSP00000405573 | aldolase C, fructose-bisphosphate | glucose-6-phosphate isomerase; Besides it’s role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons | 0.982 |
ALDOC | PFKL | ENSP00000226253 | ENSP00000269848 | aldolase C, fructose-bisphosphate | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.989 |
ALDOC | PFKM | ENSP00000226253 | ENSP00000345771 | aldolase C, fructose-bisphosphate | phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.988 |
ALDOC | PFKP | ENSP00000226253 | ENSP00000370517 | aldolase C, fructose-bisphosphate | phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.988 |
ALDOC | PKM | ENSP00000226253 | ENSP00000320171 | aldolase C, fructose-bisphosphate | pyruvate kinase, muscle | 0.986 |