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ROPN1 ROPN1 AKAP3 AKAP3 ROPN1L ROPN1L AKAP7 AKAP7 ZPBP ZPBP SPA17 SPA17 PRSS50 PRSS50 GAS2L1 GAS2L1 RASL10A RASL10A GAS2L2 GAS2L2 GAS2 GAS2
"SPA17" - sperm autoantigenic protein 17 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
SPA17sperm autoantigenic protein 17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity) (151 aa)    
Predicted Functional Partners:
ROPN1
rhophilin associated tail protein 1 (212 aa)
        score_image   score_image   0.985
AKAP3
A kinase (PRKA) anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction (853 aa)
        score_image   score_image   0.938
ROPN1L
rhophilin associated tail protein 1-like (230 aa)
            score_image   0.862
AKAP7
A kinase (PRKA) anchor protein 7; Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (348 aa)
        score_image       0.786
GAS2L2
growth arrest-specific 2 like 2; Seems to be involved in the cross-linking of microtubules and microfilaments (880 aa)
            score_image   0.757
ZPBP
zona pellucida binding protein; May be implicated in gamete interaction during fertilization (351 aa)
            score_image   0.757
RASL10A
RAS-like, family 10, member A; Potent inhibitor of cellular proliferation (203 aa)
            score_image   0.754
GAS2L1
growth arrest-specific 2 like 1; Seems to be involved in the cross-linking of microtubules and microfilaments (337 aa)
            score_image   0.747
GAS2
growth arrest-specific 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity) (313 aa)
            score_image   0.742
PRSS50
protease, serine, 50; May be involved in proteolysis through its threonine endopeptidase activity (385 aa)
            score_image   0.727
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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