Export your current network:
... as a bitmap image:
file format is 'PNG': portable network graphic
... as a high-resolution bitmap:
same PNG format, but resolution at 400 dpi
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as simple tabular text output:
TSV: tab separated values - can be opened in Excel
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and annotated functions of the network proteins
Browse interactions in tabular form:
node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANO6 | CTSC | ENSP00000409126 | ENSP00000227266 | anoctamin 6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes | cathepsin C | 0.656 |
BMP4 | CTSC | ENSP00000245451 | ENSP00000227266 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | cathepsin C | 0.814 |
BMP4 | NOG | ENSP00000245451 | ENSP00000328181 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite | 0.998 |
CD81 | CTSC | ENSP00000263645 | ENSP00000227266 | CD81 molecule; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV | cathepsin C | 0.691 |
CDIPT | CTSC | ENSP00000219789 | ENSP00000227266 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme | cathepsin C | 0.644 |
CST7 | CTSC | ENSP00000420384 | ENSP00000227266 | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | cathepsin C | 0.628 |
CST7 | CTSL1 | ENSP00000420384 | ENSP00000345344 | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | cathepsin L1; Important for the overall degradation of proteins in lysosomes | 0.665 |
CTSC | ANO6 | ENSP00000227266 | ENSP00000409126 | cathepsin C | anoctamin 6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes | 0.656 |
CTSC | BMP4 | ENSP00000227266 | ENSP00000245451 | cathepsin C | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.814 |
CTSC | CD81 | ENSP00000227266 | ENSP00000263645 | cathepsin C | CD81 molecule; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV | 0.691 |
CTSC | CDIPT | ENSP00000227266 | ENSP00000219789 | cathepsin C | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme | 0.644 |
CTSC | CST7 | ENSP00000227266 | ENSP00000420384 | cathepsin C | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | 0.628 |
CTSC | CTSL1 | ENSP00000227266 | ENSP00000345344 | cathepsin C | cathepsin L1; Important for the overall degradation of proteins in lysosomes | 0.672 |
CTSC | GLT6D1 | ENSP00000227266 | ENSP00000360829 | cathepsin C | glycosyltransferase 6 domain containing 1 | 0.748 |
CTSC | GZMA | ENSP00000227266 | ENSP00000274306 | cathepsin C | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after ’Lys-31’ and destroys its oxidative repair activity. Involved in apoptosis | 0.681 |
CTSC | HSP90B1 | ENSP00000227266 | ENSP00000299767 | cathepsin C | heat shock protein 90kDa beta (Grp94), member 1; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity | 0.802 |
CTSC | NOG | ENSP00000227266 | ENSP00000328181 | cathepsin C | noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite | 0.806 |
CTSL1 | CST7 | ENSP00000345344 | ENSP00000420384 | cathepsin L1; Important for the overall degradation of proteins in lysosomes | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | 0.665 |
CTSL1 | CTSC | ENSP00000345344 | ENSP00000227266 | cathepsin L1; Important for the overall degradation of proteins in lysosomes | cathepsin C | 0.672 |
GLT6D1 | CTSC | ENSP00000360829 | ENSP00000227266 | glycosyltransferase 6 domain containing 1 | cathepsin C | 0.748 |
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