CTSC protein (Homo sapiens) - STRING network view

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Score

CTSC

cathepsin C (463 aa)

Predicted Functional Partners:

BMP4

0.814

NOG

0.806

HSP90B1

0.802

GLT6D1

0.748

CD81

0.691

GZMA

0.681

CTSL1

0.672

ANO6

0.656

CDIPT

0.644

CST7

0.628

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANO6	CTSC	ENSP00000409126	ENSP00000227266	anoctamin 6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes	cathepsin C	0.656
BMP4	CTSC	ENSP00000245451	ENSP00000227266	bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)	cathepsin C	0.814
BMP4	NOG	ENSP00000245451	ENSP00000328181	bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)	noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite	0.998
CD81	CTSC	ENSP00000263645	ENSP00000227266	CD81 molecule; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV	cathepsin C	0.691
CDIPT	CTSC	ENSP00000219789	ENSP00000227266	CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme	cathepsin C	0.644
CST7	CTSC	ENSP00000420384	ENSP00000227266	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system	cathepsin C	0.628
CST7	CTSL1	ENSP00000420384	ENSP00000345344	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system	cathepsin L1; Important for the overall degradation of proteins in lysosomes	0.665
CTSC	ANO6	ENSP00000227266	ENSP00000409126	cathepsin C	anoctamin 6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes	0.656
CTSC	BMP4	ENSP00000227266	ENSP00000245451	cathepsin C	bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity)	0.814
CTSC	CD81	ENSP00000227266	ENSP00000263645	cathepsin C	CD81 molecule; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV	0.691
CTSC	CDIPT	ENSP00000227266	ENSP00000219789	cathepsin C	CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns-inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme	0.644
CTSC	CST7	ENSP00000227266	ENSP00000420384	cathepsin C	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system	0.628
CTSC	CTSL1	ENSP00000227266	ENSP00000345344	cathepsin C	cathepsin L1; Important for the overall degradation of proteins in lysosomes	0.672
CTSC	GLT6D1	ENSP00000227266	ENSP00000360829	cathepsin C	glycosyltransferase 6 domain containing 1	0.748
CTSC	GZMA	ENSP00000227266	ENSP00000274306	cathepsin C	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after ’Lys-31’ and destroys its oxidative repair activity. Involved in apoptosis	0.681
CTSC	HSP90B1	ENSP00000227266	ENSP00000299767	cathepsin C	heat shock protein 90kDa beta (Grp94), member 1; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity	0.802
CTSC	NOG	ENSP00000227266	ENSP00000328181	cathepsin C	noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite	0.806
CTSL1	CST7	ENSP00000345344	ENSP00000420384	cathepsin L1; Important for the overall degradation of proteins in lysosomes	cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system	0.665
CTSL1	CTSC	ENSP00000345344	ENSP00000227266	cathepsin L1; Important for the overall degradation of proteins in lysosomes	cathepsin C	0.672
GLT6D1	CTSC	ENSP00000360829	ENSP00000227266	glycosyltransferase 6 domain containing 1	cathepsin C	0.748

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