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BCAS2 BCAS2 BAG1 BAG1 UBC UBC BAG2 BAG2 HSPA8 HSPA8 DNAJA1 DNAJA1 STUB1 STUB1 CFTR CFTR HSP90AA1 HSP90AA1 DNAJB1 DNAJB1 DNAJB6 DNAJB6
"HSPA8" - heat shock 70kDa protein 8 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
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gene co-occurrence
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protein homology
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HSPA8heat shock 70kDa protein 8; Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19- CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (646 aa)    
Predicted Functional Partners:
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (854 aa)
      score_image score_image score_image score_image   0.999
BAG1
BCL2-associated athanogene (345 aa)
        score_image   score_image   0.999
UBC
ubiquitin C (685 aa)
      score_image score_image score_image score_image   0.999
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP (340 aa)
score_image   score_image score_image score_image score_image score_image   0.999
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1 (1480 aa)
        score_image   score_image   0.999
STUB1
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates- ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 th [...] (303 aa)
        score_image   score_image   0.999
DNAJB6
DnaJ (Hsp40) homolog, subfamily B, member 6 (326 aa)
score_image   score_image score_image score_image score_image score_image   0.999
DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1; Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria (397 aa)
score_image   score_image score_image score_image   score_image   0.999
BCAS2
breast carcinoma amplified sequence 2; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (225 aa)
        score_image   score_image   0.999
BAG2
BCL2-associated athanogene 2; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (211 aa)
        score_image   score_image   0.998
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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