PUS3 protein (Homo sapiens) - STRING network view

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PUS3

pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity) (481 aa)

Predicted Functional Partners:

TRUB1

0.887

LMNA

0.798

PUS7

0.774

DDX25

0.692

RPL13A

0.684

LMNB2

0.665

IMP3

0.661

LMNB1

0.657

PKNOX2

0.654

RPS9

0.641

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX25	PKNOX2	ENSP00000263576	ENSP00000298282	DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity)	PBX/knotted 1 homeobox 2	0.861
DDX25	PUS3	ENSP00000263576	ENSP00000227474	DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity)	pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity)	0.692
IMP3	PUS3	ENSP00000326981	ENSP00000227474	IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing	pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity)	0.661
IMP3	RPL13A	ENSP00000326981	ENSP00000375730	IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing	ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3’-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses [...]	0.962
IMP3	TRUB1	ENSP00000326981	ENSP00000298746	IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing	TruB pseudouridine (psi) synthase homolog 1 (E. coli); May be responsible for synthesis of pseudouridine from uracil in transfer RNAs (By similarity)	0.423
LMNA	LMNB1	ENSP00000357283	ENSP00000261366	lamin A/C	lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	0.992
LMNA	LMNB2	ENSP00000357283	ENSP00000462730	lamin A/C	lamin B2; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	0.957
LMNA	PUS3	ENSP00000357283	ENSP00000227474	lamin A/C	pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity)	0.798
LMNB1	LMNA	ENSP00000261366	ENSP00000357283	lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	lamin A/C	0.992
LMNB1	LMNB2	ENSP00000261366	ENSP00000462730	lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	lamin B2; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	0.903
LMNB1	PUS3	ENSP00000261366	ENSP00000227474	lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity)	0.657
LMNB2	LMNA	ENSP00000462730	ENSP00000357283	lamin B2; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	lamin A/C	0.957
LMNB2	LMNB1	ENSP00000462730	ENSP00000261366	lamin B2; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	0.903
LMNB2	PUS3	ENSP00000462730	ENSP00000227474	lamin B2; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity)	0.665
PKNOX2	DDX25	ENSP00000298282	ENSP00000263576	PBX/knotted 1 homeobox 2	DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity)	0.861
PKNOX2	PUS3	ENSP00000298282	ENSP00000227474	PBX/knotted 1 homeobox 2	pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity)	0.654
PUS3	DDX25	ENSP00000227474	ENSP00000263576	pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity)	DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity)	0.692
PUS3	IMP3	ENSP00000227474	ENSP00000326981	pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity)	IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing	0.661
PUS3	LMNA	ENSP00000227474	ENSP00000357283	pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity)	lamin A/C	0.798
PUS3	LMNB1	ENSP00000227474	ENSP00000261366	pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity)	lamin B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin	0.657

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