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STRINGSTRING
LYZ LYZ PRDM10 PRDM10 MT-CYB MT-CYB ALB ALB MRC1 MRC1 CLEC3A CLEC3A CLEC2B CLEC2B NKRF NKRF NPR2 NPR2 HCCS HCCS NPPC NPPC
"CLEC2B" - C-type lectin domain family 2, member B in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
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[Homology]
Score
CLEC2BC-type lectin domain family 2, member B (149 aa)    
Predicted Functional Partners:
CLEC3A
C-type lectin domain family 3, member A; Promotes cell adhesion to laminin-332 and fibronectin (197 aa)
            score_image   0.800
MT-CYB
mitochondrially encoded cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) (380 aa)
            score_image   0.757
HCCS
holocytochrome c synthase; Links covalently the heme group to the apoprotein of cytochrome c (By similarity) (268 aa)
            score_image   0.631
LYZ
lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents (148 aa)
            score_image   0.623
MRC1
mannose receptor, C type 1; Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens (1456 aa)
            score_image   0.584
NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) (1047 aa)
            score_image   0.560
PRDM10
PR domain containing 10 (1160 aa)
            score_image   0.539
ALB
albumin (609 aa)
            score_image   0.510
NPPC
natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity) (126 aa)
            score_image   0.472
NKRF
NFKB repressing factor; Interacts with a specific negative regulatory element (NRE) 5’-AATTCCTCTGA-3’ to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription (705 aa)
            score_image   0.471
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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