SELPLG protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SELPLG

selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture (428 aa)

Predicted Functional Partners:

SELP

0.998

SELE

0.981

SELL

0.973

SPN

0.958

ITGAM

0.937

CD44

0.935

GLG1

0.927

ITGB2

0.919

ESAM

0.917

SNX20

0.890

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD44	GLG1	ENSP00000398632	ENSP00000205061	CD44 molecule (Indian blood group)	golgi glycoprotein 1; Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils)	0.918
CD44	ITGAM	ENSP00000398632	ENSP00000441691	CD44 molecule (Indian blood group)	integrin, alpha M (complement component 3 receptor 3 subunit); Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain	0.507
CD44	SELE	ENSP00000398632	ENSP00000331736	CD44 molecule (Indian blood group)	selectin E; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis	0.987
CD44	SELL	ENSP00000398632	ENSP00000236147	CD44 molecule (Indian blood group)	selectin L; Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity)	0.706
CD44	SELP	ENSP00000398632	ENSP00000263686	CD44 molecule (Indian blood group)	selectin P (granule membrane protein 140kDa, antigen CD62); Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1	0.407
CD44	SELPLG	ENSP00000398632	ENSP00000228463	CD44 molecule (Indian blood group)	selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture	0.935
CD44	SPN	ENSP00000398632	ENSP00000353238	CD44 molecule (Indian blood group)	sialophorin; One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response [...]	0.955
ESAM	ITGAM	ENSP00000278927	ENSP00000441691	endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity)	integrin, alpha M (complement component 3 receptor 3 subunit); Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain	0.480
ESAM	ITGB2	ENSP00000278927	ENSP00000303242	endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity)	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration dur [...]	0.471
ESAM	SELE	ENSP00000278927	ENSP00000331736	endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity)	selectin E; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis	0.954
ESAM	SELL	ENSP00000278927	ENSP00000236147	endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity)	selectin L; Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity)	0.937
ESAM	SELP	ENSP00000278927	ENSP00000263686	endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity)	selectin P (granule membrane protein 140kDa, antigen CD62); Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1	0.948
ESAM	SELPLG	ENSP00000278927	ENSP00000228463	endothelial cell adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction (By similarity)	selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture	0.917
GLG1	CD44	ENSP00000205061	ENSP00000398632	golgi glycoprotein 1; Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils)	CD44 molecule (Indian blood group)	0.918
GLG1	SELE	ENSP00000205061	ENSP00000331736	golgi glycoprotein 1; Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils)	selectin E; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis	0.985
GLG1	SELL	ENSP00000205061	ENSP00000236147	golgi glycoprotein 1; Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils)	selectin L; Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity)	0.614
GLG1	SELP	ENSP00000205061	ENSP00000263686	golgi glycoprotein 1; Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils)	selectin P (granule membrane protein 140kDa, antigen CD62); Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1	0.449
GLG1	SELPLG	ENSP00000205061	ENSP00000228463	golgi glycoprotein 1; Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils)	selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture	0.927
GLG1	SPN	ENSP00000205061	ENSP00000353238	golgi glycoprotein 1; Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils)	sialophorin; One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response [...]	0.905
ITGAM	CD44	ENSP00000441691	ENSP00000398632	integrin, alpha M (complement component 3 receptor 3 subunit); Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain	CD44 molecule (Indian blood group)	0.507

page 1 of 4

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About