| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD2BP2 | MVK | ENSP00000304903 | ENSP00000228510 | CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly | mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway | 0.860 |
| HMGCR | HMGCS1 | ENSP00000287936 | ENSP00000322706 | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.994 |
| HMGCR | MVD | ENSP00000287936 | ENSP00000301012 | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes | 0.809 |
| HMGCR | MVK | ENSP00000287936 | ENSP00000228510 | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway | 0.987 |
| HMGCR | NFYA | ENSP00000287936 | ENSP00000345702 | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | nuclear transcription factor Y, alpha; Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes | 0.902 |
| HMGCR | NFYB | ENSP00000287936 | ENSP00000240055 | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | nuclear transcription factor Y, beta; Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes | 0.901 |
| HMGCR | NFYC | ENSP00000287936 | ENSP00000396620 | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | nuclear transcription factor Y, gamma | 0.900 |
| HMGCR | PMVK | ENSP00000287936 | ENSP00000357452 | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | phosphomevalonate kinase | 0.744 |
| HMGCR | SREBF2 | ENSP00000287936 | ENSP00000354476 | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | sterol regulatory element binding transcription factor 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes | 0.987 |
| HMGCS1 | HMGCR | ENSP00000322706 | ENSP00000287936 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | 0.994 |
| HMGCS1 | MVD | ENSP00000322706 | ENSP00000301012 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes | 0.958 |
| HMGCS1 | MVK | ENSP00000322706 | ENSP00000228510 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway | 0.916 |
| HMGCS1 | NFYA | ENSP00000322706 | ENSP00000345702 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | nuclear transcription factor Y, alpha; Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes | 0.916 |
| HMGCS1 | NFYB | ENSP00000322706 | ENSP00000240055 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | nuclear transcription factor Y, beta; Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters, for example in type 1 collagen, albumin and beta-actin genes | 0.906 |
| HMGCS1 | NFYC | ENSP00000322706 | ENSP00000396620 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | nuclear transcription factor Y, gamma | 0.913 |
| HMGCS1 | PMVK | ENSP00000322706 | ENSP00000357452 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | phosphomevalonate kinase | 0.553 |
| HMGCS1 | SREBF2 | ENSP00000322706 | ENSP00000354476 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | sterol regulatory element binding transcription factor 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes | 0.974 |
| MVD | HMGCR | ENSP00000301012 | ENSP00000287936 | mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes | 3-hydroxy-3-methylglutaryl-CoA reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins | 0.809 |
| MVD | HMGCS1 | ENSP00000301012 | ENSP00000322706 | mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.958 |
| MVD | MVK | ENSP00000301012 | ENSP00000228510 | mevalonate (diphospho) decarboxylase; Performs the first committed step in the biosynthesis of isoprenes | mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway | 0.947 |
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