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ENSG00000250151 ENSG00000250151 ARPC1B ARPC1B ARPC5 ARPC5 ARPC2 ARPC2 ACTR2 ACTR2 ARPC4 ARPC4 ARPC3 ARPC3 WASL WASL ARPC5L ARPC5L ACTR3 ACTR3 ARPC1A ARPC1A
"ARPC3" - actin related protein 2/3 complex, subunit 3, 21kDa in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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experiment edge
experimentally determined
Predicted Interactions
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fusion edge
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cooccurrence edge
gene co-occurrence
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textmining
coexpression edge
co-expression
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protein homology
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ARPC3actin related protein 2/3 complex, subunit 3, 21kDa; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (178 aa)    
Predicted Functional Partners:
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (187 aa)
      score_image score_image score_image score_image   0.999
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (300 aa)
      score_image score_image score_image score_image   0.999
ACTR2
ARP2 actin-related protein 2 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (399 aa)
        score_image score_image score_image   0.999
ARPC1B
actin related protein 2/3 complex, subunit 1B, 41kDa; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (372 aa)
        score_image score_image score_image   0.999
ARPC5
actin related protein 2/3 complex, subunit 5, 16kDa; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (151 aa)
      score_image score_image score_image score_image   0.999
ACTR3
ARP3 actin-related protein 3 homolog (yeast); Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis (418 aa)
      score_image score_image score_image score_image   0.999
ARPC5L
actin related protein 2/3 complex, subunit 5-like; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity) (153 aa)
      score_image score_image   score_image   0.999
ARPC1A
actin related protein 2/3 complex, subunit 1A, 41kDa; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (370 aa)
        score_image score_image score_image   0.999
ENSG00000250151
ARPC4-TTLL3 readthrough; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (625 aa)
      score_image score_image score_image score_image   0.994
WASL
Wiskott-Aldrich syndrome-like; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (505 aa)
        score_image score_image score_image   0.987
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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