| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IFNG | IFNGR1 | ENSP00000229135 | ENSP00000356713 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer | 0.999 |
| IFNG | IFNGR2 | ENSP00000229135 | ENSP00000290219 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2 | 0.970 |
| IFNG | IL18 | ENSP00000229135 | ENSP00000280357 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells | 0.957 |
| IFNG | IL18R1 | ENSP00000229135 | ENSP00000233957 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | 0.982 |
| IFNG | IL2 | ENSP00000229135 | ENSP00000226730 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.978 |
| IFNG | IRF1 | ENSP00000229135 | ENSP00000245414 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] | 0.985 |
| IFNG | STAT1 | ENSP00000229135 | ENSP00000354394 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | signal transducer and activator of transcription 1, 91kDa | 0.995 |
| IFNG | TBX21 | ENSP00000229135 | ENSP00000177694 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | T-box 21; Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs | 0.989 |
| IFNG | TGFB1 | ENSP00000229135 | ENSP00000221930 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.955 |
| IFNG | TNF | ENSP00000229135 | ENSP00000398698 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | tumor necrosis factor | 0.994 |
| IFNGR1 | IFNG | ENSP00000356713 | ENSP00000229135 | interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | 0.999 |
| IFNGR1 | IFNGR2 | ENSP00000356713 | ENSP00000290219 | interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer | interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2 | 0.980 |
| IFNGR1 | IL2 | ENSP00000356713 | ENSP00000226730 | interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.813 |
| IFNGR1 | STAT1 | ENSP00000356713 | ENSP00000354394 | interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer | signal transducer and activator of transcription 1, 91kDa | 0.999 |
| IFNGR2 | IFNG | ENSP00000290219 | ENSP00000229135 | interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | 0.970 |
| IFNGR2 | IFNGR1 | ENSP00000290219 | ENSP00000356713 | interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2 | interferon gamma receptor 1; Receptor for interferon gamma. Two receptors bind one interferon gamma dimer | 0.980 |
| IFNGR2 | IL2 | ENSP00000290219 | ENSP00000226730 | interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2 | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.800 |
| IFNGR2 | STAT1 | ENSP00000290219 | ENSP00000354394 | interferon gamma receptor 2 (interferon gamma transducer 1); Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2 | signal transducer and activator of transcription 1, 91kDa | 0.853 |
| IL18 | IFNG | ENSP00000280357 | ENSP00000229135 | interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | 0.957 |
| IL18 | IL18R1 | ENSP00000280357 | ENSP00000233957 | interleukin 18 (interferon-gamma-inducing factor); Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells | interleukin 18 receptor 1; Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B | 0.991 |
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