node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACR | ACRBP | ENSP00000216139 | ENSP00000229243 | acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome | acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) | 0.581 |
ACR | ADAM2 | ENSP00000216139 | ENSP00000265708 | acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | 0.480 |
ACR | ZPBP | ENSP00000216139 | ENSP00000046087 | acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome | zona pellucida binding protein; May be implicated in gamete interaction during fertilization | 0.563 |
ACRBP | ACR | ENSP00000229243 | ENSP00000216139 | acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) | acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome | 0.581 |
ACRBP | ADAM2 | ENSP00000229243 | ENSP00000265708 | acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | 0.585 |
ACRBP | BRDT | ENSP00000229243 | ENSP00000354568 | acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) | bromodomain, testis-specific | 0.514 |
ACRBP | LIPI | ENSP00000229243 | ENSP00000343331 | acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) | lipase, member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG) | 0.564 |
ACRBP | MAGEC1 | ENSP00000229243 | ENSP00000285879 | acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) | melanoma antigen family C, 1 | 0.632 |
ACRBP | MAGEC2 | ENSP00000229243 | ENSP00000354660 | acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) | melanoma antigen family C, 2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex | 0.505 |
ACRBP | MUC1 | ENSP00000229243 | ENSP00000357380 | acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) | mucin 1, cell surface associated | 0.746 |
ACRBP | PAGE5 | ENSP00000229243 | ENSP00000289619 | acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) | P antigen family, member 5 (prostate associated) | 0.565 |
ACRBP | SPA17 | ENSP00000229243 | ENSP00000227135 | acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) | sperm autoantigenic protein 17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity) | 0.659 |
ACRBP | ZPBP | ENSP00000229243 | ENSP00000046087 | acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) | zona pellucida binding protein; May be implicated in gamete interaction during fertilization | 0.534 |
ADAM2 | ACR | ENSP00000265708 | ENSP00000216139 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome | 0.480 |
ADAM2 | ACRBP | ENSP00000265708 | ENSP00000229243 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | acrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) | 0.585 |
ADAM2 | BRDT | ENSP00000265708 | ENSP00000354568 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | bromodomain, testis-specific | 0.601 |
ADAM2 | LIPI | ENSP00000265708 | ENSP00000343331 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | lipase, member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG) | 0.562 |
ADAM2 | MAGEC1 | ENSP00000265708 | ENSP00000285879 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | melanoma antigen family C, 1 | 0.457 |
ADAM2 | PAGE5 | ENSP00000265708 | ENSP00000289619 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | P antigen family, member 5 (prostate associated) | 0.631 |
ADAM2 | SPA17 | ENSP00000265708 | ENSP00000227135 | ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein | sperm autoantigenic protein 17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity) | 0.509 |