Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
MAGEC2 MAGEC2 PAGE5 PAGE5 LIPI LIPI BRDT BRDT MUC1 MUC1 SPA17 SPA17 ACRBP ACRBP MAGEC1 MAGEC1 ADAM2 ADAM2 ZPBP ZPBP ACR ACR
"ACRBP" - acrosin binding protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACRBPacrosin binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin (By similarity) (543 aa)    
Predicted Functional Partners:
MUC1
mucin 1, cell surface associated (475 aa)
            score_image   0.746
SPA17
sperm autoantigenic protein 17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity) (151 aa)
            score_image   0.659
MAGEC1
melanoma antigen family C, 1 (1142 aa)
            score_image   0.632
ADAM2
ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (735 aa)
            score_image   0.585
ACR
acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome (421 aa)
            score_image   0.581
PAGE5
P antigen family, member 5 (prostate associated) (130 aa)
            score_image   0.565
LIPI
lipase, member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG) (481 aa)
            score_image   0.564
ZPBP
zona pellucida binding protein; May be implicated in gamete interaction during fertilization (351 aa)
            score_image   0.534
BRDT
bromodomain, testis-specific (947 aa)
            score_image   0.514
MAGEC2
melanoma antigen family C, 2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3-substrate complex (373 aa)
            score_image   0.505
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (31%)